Endosomal proteolysis and MHC class II function - PubMed (original) (raw)
Review
Endosomal proteolysis and MHC class II function
H A Chapman. Curr Opin Immunol. 1998 Feb.
Abstract
Newly synthesized MHC class II alpha and beta chains associate with a protein chaperone, the invariant chain, which promotes the proper assembly of MHC class II complexes and their trafficking through cells and prevents their untimely loading with peptides. Efficient loading of MHC class II heterodimers with antigenic peptides requires concurrent proteolytic processing of both the invariant chain and endocytosed proteins. Recent studies have elucidated the critical roles of specific cysteine proteases, especially cathepsins S and L, in degrading the invariant chain and regulating the convergence of processed antigen and MHC class II dimers competent for peptide loading.
Similar articles
- Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages.
Shi GP, Bryant RA, Riese R, Verhelst S, Driessen C, Li Z, Bromme D, Ploegh HL, Chapman HA. Shi GP, et al. J Exp Med. 2000 Apr 3;191(7):1177-86. doi: 10.1084/jem.191.7.1177. J Exp Med. 2000. PMID: 10748235 Free PMC article. - Cathepsins and compartmentalization in antigen presentation.
Riese RJ, Chapman HA. Riese RJ, et al. Curr Opin Immunol. 2000 Feb;12(1):107-13. doi: 10.1016/s0952-7915(99)00058-8. Curr Opin Immunol. 2000. PMID: 10679409 Review. - Endosomal proteases and antigen processing.
Fineschi B, Miller J. Fineschi B, et al. Trends Biochem Sci. 1997 Oct;22(10):377-82. doi: 10.1016/s0968-0004(97)01116-x. Trends Biochem Sci. 1997. PMID: 9357312 Review.
Cited by
- Antigen Presentation and Autophagy in Teleost Adaptive Immunity.
Johnstone C, Chaves-Pozo E. Johnstone C, et al. Int J Mol Sci. 2022 Apr 28;23(9):4899. doi: 10.3390/ijms23094899. Int J Mol Sci. 2022. PMID: 35563287 Free PMC article. Review. - A Missing Switch in Peptide Exchange for MHC Class II Molecules.
Freund C, Höfer T. Freund C, et al. Front Immunol. 2019 Oct 23;10:2513. doi: 10.3389/fimmu.2019.02513. eCollection 2019. Front Immunol. 2019. PMID: 31708929 Free PMC article. Review. No abstract available. - Establishment of Peritoneal and Hepatic Metastasis Mouse Xenograft Models Using Gastric Cancer Cell Lines.
Miwa T, Kanda M, Umeda S, Tanaka H, Shimizu D, Tanaka C, Kobayashi D, Hayashi M, Yamada S, Nakayama G, Koike M, Kodera Y. Miwa T, et al. In Vivo. 2019 Nov-Dec;33(6):1785-1792. doi: 10.21873/invivo.11669. In Vivo. 2019. PMID: 31662503 Free PMC article. - _N_-Glycosylation of Seasonal Influenza Vaccine Hemagglutinins: Implication for Potency Testing and Immune Processing.
An Y, Parsons LM, Jankowska E, Melnyk D, Joshi M, Cipollo JF. An Y, et al. J Virol. 2019 Jan 4;93(2):e01693-18. doi: 10.1128/JVI.01693-18. Print 2019 Jan 15. J Virol. 2019. PMID: 30355697 Free PMC article. - Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains.
Huynh JL, Garg P, Thin TH, Yoo S, Dutta R, Trapp BD, Haroutunian V, Zhu J, Donovan MJ, Sharp AJ, Casaccia P. Huynh JL, et al. Nat Neurosci. 2014 Jan;17(1):121-30. doi: 10.1038/nn.3588. Epub 2013 Nov 24. Nat Neurosci. 2014. PMID: 24270187 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials