Generation of intestinal T cells from progenitors residing in gut cryptopatches - PubMed (original) (raw)
Generation of intestinal T cells from progenitors residing in gut cryptopatches
H Saito et al. Science. 1998.
Abstract
Cryptopatches (CPs) are part of the murine intestinal immune compartment. Cells isolated from CPs of the small intestine that were c-kit positive (c-kit+) but lineage markers negative (Lin-) gave rise to T cell receptor (TCR) alphabeta and TCR gammadelta intestinal intraepithelial T cells after in vivo transfer or tissue engraftment into severe combined immunodeficient mice. In contrast, cells from Peyer's patches and mesenteric lymph nodes, which belong in the same intestinal immune compartment but lack c-kit+Lin- cells, failed to do so. These findings and results of electron microscopic analysis provide evidence of a local intestinal T cell precursor that develops in the CPs.
Comment in
- T cells on the mucosal frontline.
Williams N. Williams N. Science. 1998 Apr 10;280(5361):198-200. doi: 10.1126/science.280.5361.198. Science. 1998. PMID: 9565528 No abstract available.
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