Capture of an early fusion-active conformation of HIV-1 gp41 - PubMed (original) (raw)
Capture of an early fusion-active conformation of HIV-1 gp41
R A Furuta et al. Nat Struct Biol. 1998 Apr.
Erratum in
- Nat Struct Biol 1998 Jul;5(7):612
Abstract
Using an inhibitory synthetic peptide (DP-178) from HIV-1 gp41, we have trapped HIV-1 envelope glycoprotein (Env) undergoing conformational changes during virus entry. Our data show that DP-178 binds gp41 and inhibits Env-mediated membrane fusion after gp120 interacts with cellular receptors, indicating that conformational changes involving the coiled coil domain of gp41 are required for entry. Capture of this fusion-active conformation of Env provides insights into the early events leading to Env-mediated membrane fusion.
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