Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara - PubMed (original) (raw)
Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara
J Schneider et al. Nat Med. 1998 Apr.
Abstract
Immunization with irradiated sporozoites can protect against malaria infection and intensive efforts are aimed at reproducing this effect with subunit vaccines. A particular sequence of subunit immunization with pre-erythrocytic antigens of Plasmodium berghei, consisting of single dose priming with plasmid DNA followed by a single boost with a recombinant modified vaccinia virus Ankara (MVA) expressing the same antigen, induced unprecedented complete protection against P. berghei sporozoite challenge in two strains of mice. Protection was associated with very high levels of splenic peptide-specific interferon-gamma-secreting CD8+ T cells and was abrogated when the order of immunization was reversed. DNA priming followed by MVA boosting may provide a general immunization regime for induction of high levels of CD8+ T cells.
Similar articles
- Enhanced CD8+ T cell immune responses and protection elicited against Plasmodium berghei malaria by prime boost immunization regimens using a novel attenuated fowlpox virus.
Anderson RJ, Hannan CM, Gilbert SC, Laidlaw SM, Sheu EG, Korten S, Sinden R, Butcher GA, Skinner MA, Hill AV. Anderson RJ, et al. J Immunol. 2004 Mar 1;172(5):3094-100. doi: 10.4049/jimmunol.172.5.3094. J Immunol. 2004. PMID: 14978115 - IL-12p40-independent induction of protective immunity upon multiple Plasmodium berghei irradiated sporozoite immunizations.
Romero JF, Ibrahim GH, Renggli J, Himmelrich H, Graber P, Corradin G. Romero JF, et al. Parasite Immunol. 2007 Nov;29(11):541-8. doi: 10.1111/j.1365-3024.2007.00972.x. Parasite Immunol. 2007. PMID: 17944743 - Progress in DNA-based heterologous prime-boost immunization strategies for malaria.
Moore AC, Hill AV. Moore AC, et al. Immunol Rev. 2004 Jun;199:126-43. doi: 10.1111/j.0105-2896.2004.00138.x. Immunol Rev. 2004. PMID: 15233731 Review. - DNA-based vaccines for malaria: a heterologous prime-boost immunisation strategy.
Hill AV, Reece W, Gothard P, Moorthy V, Roberts M, Flanagan K, Plebanski M, Hannan C, Hu JT, Anderson R, Degano P, Schneider J, Prieur E, Sheu E, Gilbert SC. Hill AV, et al. Dev Biol (Basel). 2000;104:171-9. Dev Biol (Basel). 2000. PMID: 11713817 Review.
Cited by
- Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa.
Beavis AC, Wee EG, Akis Yildirim BM, Borthwick N, He B, Hanke T. Beavis AC, et al. Front Immunol. 2023 Jul 17;14:1186478. doi: 10.3389/fimmu.2023.1186478. eCollection 2023. Front Immunol. 2023. PMID: 37529048 Free PMC article. - Vaccinia Virus Strain MVA Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Glycoprotein Induces Robust Protection and Prevents Brain Infection in Mouse and Hamster Models.
Lorenzo MM, Marín-López A, Chiem K, Jimenez-Cabello L, Ullah I, Utrilla-Trigo S, Calvo-Pinilla E, Lorenzo G, Moreno S, Ye C, Park JG, Matía A, Brun A, Sánchez-Puig JM, Nogales A, Mothes W, Uchil PD, Kumar P, Ortego J, Fikrig E, Martinez-Sobrido L, Blasco R. Lorenzo MM, et al. Vaccines (Basel). 2023 May 21;11(5):1006. doi: 10.3390/vaccines11051006. Vaccines (Basel). 2023. PMID: 37243110 Free PMC article. - Development of Modified Vaccinia Virus Ankara-Based Vaccines: Advantages and Applications.
Orlova OV, Glazkova DV, Bogoslovskaya EV, Shipulin GA, Yudin SM. Orlova OV, et al. Vaccines (Basel). 2022 Sep 13;10(9):1516. doi: 10.3390/vaccines10091516. Vaccines (Basel). 2022. PMID: 36146594 Free PMC article. Review. - Virus-Like Particles Are Efficient Tools for Boosting mRNA-Induced Antibodies.
Vogt AS, Jörg L, Martina B, Krenger PS, Chang X, Zeltins A, Vogel M, Mohsen MO, Bachmann MF. Vogt AS, et al. Front Immunol. 2022 Jun 16;13:864718. doi: 10.3389/fimmu.2022.864718. eCollection 2022. Front Immunol. 2022. PMID: 35784292 Free PMC article. - Extracellular Vesicles and Their Use as Vehicles of Immunogens.
Chiozzini C, Ridolfi B, Federico M. Chiozzini C, et al. Methods Mol Biol. 2022;2504:177-198. doi: 10.1007/978-1-0716-2341-1_13. Methods Mol Biol. 2022. PMID: 35467287
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials