Identification of a new mouse beta-chemokine, thymus-derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells - PubMed (original) (raw)
. 1997 Dec 1;159(11):5671-9.
Affiliations
- PMID: 9548511
Identification of a new mouse beta-chemokine, thymus-derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells
S Tanabe et al. J Immunol. 1997.
Abstract
Thymus-derived chemotactic agent 4 (TCA4), a new member of the beta-chemokine family, was cloned from a mouse thymic cDNA library. High levels of TCA4 mRNA are expressed in thymus; lower levels of message are found in spleen, heart, and kidney. Anti-TCA4 antibodies were used to localize sites of TCA4 expression within lymphoid tissues. In the thymus, UEA-1+ medullary epithelial cells, some endothelial cells, and additional undefined stromal elements were stained with anti-TCA4. TCA4 was also expressed as a meshlike network in splenic white pulp and in the medullary region of the lymph nodes. In addition, some lymph node and splenic blood vessels stained with anti-TCA4 antibodies. Rel B NFkappaB-deficient mice lack a transcription factor required for the generation of dendritic cells and the development of an organized thymic medulla. Rel B-deficient animals express very low levels of TCA4 in the thymus and little or no TCA4 in the periphery. At subnanomolar concentrations, TCA4 is a chemoattractant of mature T cells; the potential role of this novel chemokine in facilitating normal lymphocyte traffic is discussed. TCA4 is also a chemoattractant of cultured mesangial cells. Neutralizing anti-TCA4 mAb was used to demonstrate the specificity of TCA4-mediated cell migration. Finally, competitive binding studies with a SV40-transformed mouse mesangial cell line demonstrated that other murine beta-chemokines (monocyte chemotactic protein-1, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and thymus-derived chemotactic agent 3) do not compete for TCA4 binding.
Similar articles
- A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes.
Hieshima K, Imai T, Baba M, Shoudai K, Ishizuka K, Nakagawa T, Tsuruta J, Takeya M, Sakaki Y, Takatsuki K, Miura R, Opdenakker G, Van Damme J, Yoshie O, Nomiyama H. Hieshima K, et al. J Immunol. 1997 Aug 1;159(3):1140-9. J Immunol. 1997. PMID: 9233607 - Cloning of the murine interferon-inducible protein 10 (IP-10) receptor and its specific expression in lymphoid organs.
Tamaru M, Tominaga Y, Yatsunami K, Narumi S. Tamaru M, et al. Biochem Biophys Res Commun. 1998 Oct 9;251(1):41-8. doi: 10.1006/bbrc.1998.9404. Biochem Biophys Res Commun. 1998. PMID: 9790904 - Expression and function of CXC and CC chemokines in human malignant liver tumors: a role for human monokine induced by gamma-interferon in lymphocyte recruitment to hepatocellular carcinoma.
Yoong KF, Afford SC, Jones R, Aujla P, Qin S, Price K, Hubscher SG, Adams DH. Yoong KF, et al. Hepatology. 1999 Jul;30(1):100-11. doi: 10.1002/hep.510300147. Hepatology. 1999. PMID: 10385645 - Regulation of macrophage-derived chemokine (MDC, CCL22) production.
Yamashita U, Kuroda E. Yamashita U, et al. Crit Rev Immunol. 2002;22(2):105-14. Crit Rev Immunol. 2002. PMID: 12433129 Review. - Cytokine production profile of early thymocytes and the characterization of a new class of chemokine.
Kelner GS, Zlotnik A. Kelner GS, et al. J Leukoc Biol. 1995 May;57(5):778-81. doi: 10.1002/jlb.57.5.778. J Leukoc Biol. 1995. PMID: 7759958 Review.
Cited by
- Migrating Myeloid Cells Sense Temporal Dynamics of Chemoattractant Concentrations.
Petrie Aronin CE, Zhao YM, Yoon JS, Morgan NY, Prüstel T, Germain RN, Meier-Schellersheim M. Petrie Aronin CE, et al. Immunity. 2017 Nov 21;47(5):862-874.e3. doi: 10.1016/j.immuni.2017.10.020. Immunity. 2017. PMID: 29166587 Free PMC article. - The chemokine receptor CCR7 expressed by dendritic cells: a key player in corneal and ocular surface inflammation.
Saban DR. Saban DR. Ocul Surf. 2014 Apr;12(2):87-99. doi: 10.1016/j.jtos.2013.10.007. Epub 2013 Dec 31. Ocul Surf. 2014. PMID: 24725321 Free PMC article. Review. - Differential requirement for CCR4 in the maintenance but not establishment of the invariant Vγ5(+) dendritic epidermal T-cell pool.
Nakamura K, White AJ, Parnell SM, Lane PJ, Jenkinson EJ, Jenkinson WE, Anderson G. Nakamura K, et al. PLoS One. 2013 Sep 12;8(9):e74019. doi: 10.1371/journal.pone.0074019. eCollection 2013. PLoS One. 2013. PMID: 24069263 Free PMC article. - Arrestin 3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21.
Byers MA, Calloway PA, Shannon L, Cunningham HD, Smith S, Li F, Fassold BC, Vines CM. Byers MA, et al. J Immunol. 2008 Oct 1;181(7):4723-32. doi: 10.4049/jimmunol.181.7.4723. J Immunol. 2008. PMID: 18802075 Free PMC article. - Fibroblast-type reticular stromal cells regulate the lymph node vasculature.
Chyou S, Ekland EH, Carpenter AC, Tzeng TC, Tian S, Michaud M, Madri JA, Lu TT. Chyou S, et al. J Immunol. 2008 Sep 15;181(6):3887-96. doi: 10.4049/jimmunol.181.6.3887. J Immunol. 2008. PMID: 18768843 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Molecular Biology Databases
Research Materials