Reaction between S-nitrosothiols and thiols: generation of nitroxyl (HNO) and subsequent chemistry - PubMed (original) (raw)
Comparative Study
. 1998 Apr 21;37(16):5362-71.
doi: 10.1021/bi973153g.
Affiliations
- PMID: 9548918
- DOI: 10.1021/bi973153g
Comparative Study
Reaction between S-nitrosothiols and thiols: generation of nitroxyl (HNO) and subsequent chemistry
P S Wong et al. Biochemistry. 1998.
Abstract
S-Nitrosothiols have been implicated to play key roles in a variety of physiological processes. The potential physiological importance of S-nitrosothiols prompted us to examine their reaction with thiols. We find that S-nitrosothiols can react with thiols to generate nitroxyl (HNO) and the corresponding disulfide. Further reaction of HNO with the remaining S-nitrosothiol and thiol results in the generation of other species including NO, sulfinamide, and hydroxylamine. Mechanisms are proposed that rationalize the observed products.
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