The effect of follow-up on limiting non-participation bias in genetic epidemiologic investigations - PubMed (original) (raw)

The effect of follow-up on limiting non-participation bias in genetic epidemiologic investigations

P A Romitti et al. Eur J Epidemiol. 1998 Feb.

Abstract

The use of a comprehensive follow-up strategy to limit non-participation bias was evaluated in a population-based case-control study of orofacial clefts. Birth parents were requested to provide exposure data, and index children and parents were asked to provide blood specimens. Follow-up included telephone or postal reminders every two weeks for up to three months. Consent to participate was received from 281 (76.6%) case mothers and 246 (72.4%) case fathers. The corresponding totals for controls were 279 (54.7%) and 245 (49.8%). Evaluation of participation rates by intensity of follow-up showed that 23% of case and 18% of control families consented without reminders (first stage); 81% of cases and 83% of controls agreed following one or two reminders (second stage); and the remainder of participants consented following three or more reminders (final stage). Cumulative distributions of sociodemographic characteristics differed little between second and final stage participants. Odds ratios for maternal multivitamin use were similar between second and final stage participants, whereas those for maternal and paternal smoking tended to decline. Although follow-up measures were necessary to enroll most families, use of more than two reminders did not appear to increase the representativeness of the sample; however, termination of recruitment after only two reminders would have led to different conclusions. Future studies require data collection protocols that encourage participation from all population subgroups, and one alternative is presented.

PubMed Disclaimer

Cited by

Factors affecting maternal participation in the genetic component of the National Birth Defects Prevention Study-United States, 1997-2007.
Glidewell J, Reefhuis J, Rasmussen SA, Woomert A, Hobbs C, Romitti PA, Crider KS. Glidewell J, et al. Genet Med. 2014 Apr;16(4):329-37. doi: 10.1038/gim.2013.143. Epub 2013 Sep 26. Genet Med. 2014. PMID: 24071796 Free PMC article.
Studies of gamma-aminobutyric acid type A receptor beta3 (GABRB3) and glutamic acid decarboxylase 67 (GAD67) with oral clefts.
Vieira AR, Howe A, Murray JC. Vieira AR, et al. Am J Med Genet A. 2008 Nov 1;146A(21):2828-30. doi: 10.1002/ajmg.a.32260. Am J Med Genet A. 2008. PMID: 18837046 Free PMC article. No abstract available.
MSX1 and orofacial clefting with and without tooth agenesis.
Modesto A, Moreno LM, Krahn K, King S, Lidral AC. Modesto A, et al. J Dent Res. 2006 Jun;85(6):542-6. doi: 10.1177/154405910608500612. J Dent Res. 2006. PMID: 16723652 Free PMC article.
Genetic significance of muscle segment homeo box1 gene in South Indian population for cleft lip and palate.
Prasad VS, Shivani V. Prasad VS, et al. Indian J Hum Genet. 2012 Sep;18(3):332-9. doi: 10.4103/0971-6866.107988. Indian J Hum Genet. 2012. PMID: 23716942 Free PMC article.
Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate.
Jezewski PA, Vieira AR, Nishimura C, Ludwig B, Johnson M, O'Brien SE, Daack-Hirsch S, Schultz RE, Weber A, Nepomucena B, Romitti PA, Christensen K, Orioli IM, Castilla EE, Machida J, Natsume N, Murray JC. Jezewski PA, et al. J Med Genet. 2003 Jun;40(6):399-407. doi: 10.1136/jmg.40.6.399. J Med Genet. 2003. PMID: 12807959 Free PMC article.

References

1. Psychol Bull. 1990 Nov;108(3):339-62 - PubMed
1. Am J Public Health. 1993 Dec;83(12):1768-72 - PubMed
1. AIDS. 1995 Dec;9(12):1357-65 - PubMed
1. AIDS. 1995 Mar;9(3):285-92 - PubMed
1. AIDS. 1995 Oct;9(10 ):1171-5 - PubMed

The effect of follow-up on limiting non-participation bias in genetic epidemiologic investigations - PubMed (original) (raw)