The physiology of parathyroid hormone-related protein: an emerging role as a developmental factor - PubMed (original) (raw)
Review
The physiology of parathyroid hormone-related protein: an emerging role as a developmental factor
J J Wysolmerski et al. Annu Rev Physiol. 1998.
Abstract
Parathyroid hormone-related protein (PTHrP) is the agent responsible for humoral hypercalcemia of malignancy. Its pathogenic role in this syndrome is well established and attention has focused in recent years on the elucidation of the roles played by PTHrP in normal developmental and adult physiology. This review focuses on studies of the past two years: (a) elucidation of the posttranslational processing pattern of PTHrP, the mechanisms of action of the various secretory forms of PTHrP, the role of PTHrP as an intracrine regulator of cell growth and cell death; (b) the emergence of PTHrP as a critical developmental factor in the mammary gland, epidermis, and the skeleton; and (c) the advances in understanding of the roles of PTHrP in the regulation of pancreatic islet mass, vascular smooth muscle tone and proliferation, and materno-fetal calcium transfer across the placenta.
Similar articles
- Parathyroid hormone-related protein.
Moseley JM, Gillespie MT. Moseley JM, et al. Crit Rev Clin Lab Sci. 1995;32(3):299-343. doi: 10.3109/10408369509084687. Crit Rev Clin Lab Sci. 1995. PMID: 7495499 Review. - [Parathyroid hormone related-protein and calcium homeostasis].
Riond JL, Kocabagli N, Toromanoff A, Wanner M. Riond JL, et al. Schweiz Arch Tierheilkd. 1995;137(4):117-23. Schweiz Arch Tierheilkd. 1995. PMID: 7660095 Review. French. - Defining the roles of parathyroid hormone-related protein in normal physiology.
Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF. Philbrick WM, et al. Physiol Rev. 1996 Jan;76(1):127-73. doi: 10.1152/physrev.1996.76.1.127. Physiol Rev. 1996. PMID: 8592727 Review. - Parathyroid hormone-related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets.
Clemens TL, Cormier S, Eichinger A, Endlich K, Fiaschi-Taesch N, Fischer E, Friedman PA, Karaplis AC, Massfelder T, Rossert J, Schlüter KD, Silve C, Stewart AF, Takane K, Helwig JJ. Clemens TL, et al. Br J Pharmacol. 2001 Nov;134(6):1113-36. doi: 10.1038/sj.bjp.0704378. Br J Pharmacol. 2001. PMID: 11704631 Free PMC article. Review. - Parathyroid hormone-related protein in the pancreatic islet and the cardiovascular system.
Vasavada RC, Garcia-Ocana A, Massfelder T, Dann P, Stewart AF. Vasavada RC, et al. Recent Prog Horm Res. 1998;53:305-38; discussion 338-40. Recent Prog Horm Res. 1998. PMID: 9769713 Review.
Cited by
- Osteostatin Mitigates Gouty Arthritis through the Inhibition of Caspase-1 Activation and Upregulation of Nrf2 Expression.
Catalán L, Carceller MC, Terencio MC, Alcaraz MJ, Ferrándiz ML, Montesinos MC. Catalán L, et al. Int J Mol Sci. 2024 Feb 27;25(5):2752. doi: 10.3390/ijms25052752. Int J Mol Sci. 2024. PMID: 38474000 Free PMC article. - Naringenin and β-carotene convert human white adipocytes to a beige phenotype and elevate hormone- stimulated lipolysis.
Coulter AA, Greenway FL, Zhang D, Ghosh S, Coulter CR, James SL, He Y, Cusimano LA, Rebello CJ. Coulter AA, et al. Front Endocrinol (Lausanne). 2023 Apr 17;14:1148954. doi: 10.3389/fendo.2023.1148954. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37143734 Free PMC article. - Molecular Mechanisms of PTH/PTHrP Class B GPCR Signaling and Pharmacological Implications.
Vilardaga JP, Clark LJ, White AD, Sutkeviciute I, Lee JY, Bahar I. Vilardaga JP, et al. Endocr Rev. 2023 May 8;44(3):474-491. doi: 10.1210/endrev/bnac032. Endocr Rev. 2023. PMID: 36503956 Free PMC article. - Markers for internal neoplasia in the horse.
Drozdzewska K, Gehlen H. Drozdzewska K, et al. Vet Med Sci. 2023 Jan;9(1):132-143. doi: 10.1002/vms3.1042. Epub 2022 Dec 10. Vet Med Sci. 2023. PMID: 36495211 Free PMC article. Review. - Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 in locally advanced laryngeal cancer as prognostic indicators of relapse and survival.
Almadori G, Coli A, De Corso E, Mele DA, Settimi S, Di Cintio G, Brigato F, Scannone D, Lauriola L, Ranelletti FO. Almadori G, et al. BMC Cancer. 2022 Jun 27;22(1):704. doi: 10.1186/s12885-022-09748-1. BMC Cancer. 2022. PMID: 35761298 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous