Collagen hydroxylases and the protein disulfide isomerase subunit of prolyl 4-hydroxylases - PubMed (original) (raw)
Review
Collagen hydroxylases and the protein disulfide isomerase subunit of prolyl 4-hydroxylases
K I Kivirikko et al. Adv Enzymol Relat Areas Mol Biol. 1998.
Abstract
Prolyl 4-hydroxylases catalyze the formation of 4-hydroxyproline in collagens and other proteins with an appropriate collagen-like stretch of amino acid residues. The enzyme requires Fe(II), 2-oxoglutarate, molecular oxygen, and ascorbate. This review concentrates on recent progress toward understanding the detailed mechanism of 4-hydroxylase action, including: (a) occurrence and function of the enzyme in animals; (b) general molecular properties; (c) intracellular sites of hydroxylation; (d) peptide substrates and mechanistic roles of the cosubstrates; (e) insights into the development of antifibrotic drugs; (f) studies of the enzyme's subunits and their catalytic function; and (g) mutations that lead to Ehlers-Danlos Syndrome. An account of the regulation of collagen hydroxylase activities is also provided.
Similar articles
- The catalytic mechanism of the hydroxylation reaction of peptidyl proline and lysine does not require protein disulphide-isomerase activity.
Myllylä R, Kaska DD, Kivirikko KI. Myllylä R, et al. Biochem J. 1989 Oct 15;263(2):609-11. doi: 10.1042/bj2630609. Biochem J. 1989. PMID: 2557001 Free PMC article. - Prolyl 4-hydroxylases and their protein disulfide isomerase subunit.
Kivirikko KI, Myllyharju J. Kivirikko KI, et al. Matrix Biol. 1998 Feb;16(7):357-68. doi: 10.1016/s0945-053x(98)90009-9. Matrix Biol. 1998. PMID: 9524356 Review. - Concomitant hydroxylation of proline and lysine residues in collagen using purified enzymes in vitro.
Turpeenniemi-Hujanen T, Myllylä R. Turpeenniemi-Hujanen T, et al. Biochim Biophys Acta. 1984 Jul 16;800(1):59-65. doi: 10.1016/0304-4165(84)90094-1. Biochim Biophys Acta. 1984. PMID: 6331520 - Protein hydroxylation: prolyl 4-hydroxylase, an enzyme with four cosubstrates and a multifunctional subunit.
Kivirikko KI, Myllylä R, Pihlajaniemi T. Kivirikko KI, et al. FASEB J. 1989 Mar;3(5):1609-17. FASEB J. 1989. PMID: 2537773 Review. - Prolyl and lysyl hydroxylases in collagen synthesis.
Salo AM, Myllyharju J. Salo AM, et al. Exp Dermatol. 2021 Jan;30(1):38-49. doi: 10.1111/exd.14197. Epub 2020 Oct 15. Exp Dermatol. 2021. PMID: 32969070 Review.
Cited by
- Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1α.
He W, Gasmi-Seabrook GMC, Ikura M, Lee JE, Ohh M. He W, et al. Proc Natl Acad Sci U S A. 2024 Sep 10;121(37):e2408104121. doi: 10.1073/pnas.2408104121. Epub 2024 Sep 4. Proc Natl Acad Sci U S A. 2024. PMID: 39231207 - DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression.
Akinjiyan FA, Ibitoye Z, Zhao P, Shriver LP, Patti GJ, Longmore GD, Fuh KC. Akinjiyan FA, et al. Oncogene. 2024 Jan;43(3):189-201. doi: 10.1038/s41388-023-02884-3. Epub 2023 Nov 23. Oncogene. 2024. PMID: 37996700 Free PMC article. - Cystatin C proteoforms in chronic kidney disease.
Dahl H, Meyer K, Sandnes K, Welland NL, Arnesen I, Marti HP, Dierkes J, Lysne V. Dahl H, et al. PLoS One. 2023 Feb 1;18(2):e0269436. doi: 10.1371/journal.pone.0269436. eCollection 2023. PLoS One. 2023. PMID: 36724153 Free PMC article. - Evidence for the Benefits of Melatonin in Cardiovascular Disease.
Tobeiha M, Jafari A, Fadaei S, Mirazimi SMA, Dashti F, Amiri A, Khan H, Asemi Z, Reiter RJ, Hamblin MR, Mirzaei H. Tobeiha M, et al. Front Cardiovasc Med. 2022 Jun 20;9:888319. doi: 10.3389/fcvm.2022.888319. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 35795371 Free PMC article. Review. - Collagen type XIX regulates cardiac extracellular matrix structure and ventricular function.
Sadri G, Fischer AG, Brittian KR, Elliott E, Nystoriak MA, Uchida S, Wysoczynski M, Leask A, Jones SP, Moore JB 4th. Sadri G, et al. Matrix Biol. 2022 May;109:49-69. doi: 10.1016/j.matbio.2022.03.007. Epub 2022 Mar 26. Matrix Biol. 2022. PMID: 35346795 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources