The multiplex function of nitric oxide in (auto)immunity - PubMed (original) (raw)

The multiplex function of nitric oxide in (auto)immunity

C Bogdan. J Exp Med. 1998.

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Figure 1

Figure 1

Scheme of putative interactions of iNOS, cytokines, and NK cells during the innate response to L. major. In iNOS+/+ mice, early expression of iNOS is due to IFN-α/β, which is induced by L. major. NO itself can kill Leishmania, but also mediates (directly or via expression of IL-12 and maintaining responsiveness to IL-12) the functional maturation of NK cells (cytotoxic activity and IFN-γ production). IFN-γ, in turn, suppresses the production of TGF-β, mediates parasite containment (i.e., prevents spreading of L. major from the site of infection to visceral organs), and presumably further enhances the expression of iNOS. Asterisks denote processes that are dependent on endogenous NO.

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