PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL - PubMed (original) (raw)
PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
P Tontonoz et al. Cell. 1998.
Free article
Abstract
The formation of foam cells from macrophages in the arterial wall is characterized by dramatic changes in lipid metabolism, including increased expression of scavenger receptors and the uptake of oxidized low-density lipoprotein (oxLDL). We demonstrate here that the nuclear receptor PPARgamma is induced in human monocytes following exposure to oxLDL and is expressed at high levels in the foam cells of atherosclerotic lesions. Ligand activation of the PPARgamma:RXRalpha heterodimer in myelomonocytic cell lines induces changes characteristic of monocytic differentiation and promotes uptake of oxLDL through transcriptional induction of the scavenger receptor CD36. These results reveal a novel signaling pathway controlling differentiation and lipid metabolism in monocytic cells, and suggest that endogenous PPARgamma ligands may be important regulators of gene expression during atherogenesis.
Similar articles
- Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma.
Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM. Nagy L, et al. Cell. 1998 Apr 17;93(2):229-40. doi: 10.1016/s0092-8674(00)81574-3. Cell. 1998. PMID: 9568715 - PPARgamma is not a critical mediator of primary monocyte differentiation or foam cell formation.
Patel L, Charlton SJ, Marshall IC, Moore GB, Coxon P, Moores K, Clapham JC, Newman SJ, Smith SA, Macphee CH. Patel L, et al. Biochem Biophys Res Commun. 2002 Jan 18;290(2):707-12. doi: 10.1006/bbrc.2001.6263. Biochem Biophys Res Commun. 2002. PMID: 11785957 - Advanced glycation end products-induced gene expression of scavenger receptors in cultured human monocyte-derived macrophages.
Iwashima Y, Eto M, Hata A, Kaku K, Horiuchi S, Ushikubi F, Sano H. Iwashima Y, et al. Biochem Biophys Res Commun. 2000 Oct 22;277(2):368-80. doi: 10.1006/bbrc.2000.3685. Biochem Biophys Res Commun. 2000. PMID: 11032732 - Role of CD36, the macrophage class B scavenger receptor, in atherosclerosis.
Nicholson AC, Han J, Febbraio M, Silversterin RL, Hajjar DP. Nicholson AC, et al. Ann N Y Acad Sci. 2001 Dec;947:224-8. doi: 10.1111/j.1749-6632.2001.tb03944.x. Ann N Y Acad Sci. 2001. PMID: 11795270 Review. - Scavenger receptors and oxidized low density lipoproteins.
Dhaliwal BS, Steinbrecher UP. Dhaliwal BS, et al. Clin Chim Acta. 1999 Aug;286(1-2):191-205. doi: 10.1016/s0009-8981(99)00101-1. Clin Chim Acta. 1999. PMID: 10511292 Review.
Cited by
- Beneficial effects of linoleic acid on cardiometabolic health: an update.
Jackson KH, Harris WS, Belury MA, Kris-Etherton PM, Calder PC. Jackson KH, et al. Lipids Health Dis. 2024 Sep 12;23(1):296. doi: 10.1186/s12944-024-02246-2. Lipids Health Dis. 2024. PMID: 39267068 Free PMC article. Review. - Role of mitochondria in reno-cardiac diseases: A study of bioenergetics, biogenesis, and GSH signaling in disease transition.
Lumpuy-Castillo J, Amador-Martínez I, Díaz-Rojas M, Lorenzo O, Pedraza-Chaverri J, Sánchez-Lozada LG, Aparicio-Trejo OE. Lumpuy-Castillo J, et al. Redox Biol. 2024 Oct;76:103340. doi: 10.1016/j.redox.2024.103340. Epub 2024 Sep 5. Redox Biol. 2024. PMID: 39250857 Free PMC article. Review. - CD36 restricts lipid-associated macrophages accumulation in white adipose tissues during atherogenesis.
Chen V, Zhang J, Chang J, Beg MA, Vick L, Wang D, Gupta A, Wang Y, Zhang Z, Dai W, Kim M, Song S, Pereira D, Zheng Z, Sodhi K, Shapiro JI, Silverstein RL, Malarkannan S, Chen Y. Chen V, et al. Front Cardiovasc Med. 2024 Aug 2;11:1436865. doi: 10.3389/fcvm.2024.1436865. eCollection 2024. Front Cardiovasc Med. 2024. PMID: 39156133 Free PMC article. - Lipid homeostasis in diabetic kidney disease.
Wang Y, Liu T, Wu Y, Wang L, Ding S, Hou B, Zhao H, Liu W, Li P. Wang Y, et al. Int J Biol Sci. 2024 Jul 2;20(10):3710-3724. doi: 10.7150/ijbs.95216. eCollection 2024. Int J Biol Sci. 2024. PMID: 39113692 Free PMC article. Review. - Anatomical location, sex, and age modulate adipocyte progenitor populations in perivascular adipose tissues.
Rendon CJ, Sempere L, Lauver A, Watts SW, Contreras GA. Rendon CJ, et al. Front Physiol. 2024 Jul 12;15:1411218. doi: 10.3389/fphys.2024.1411218. eCollection 2024. Front Physiol. 2024. PMID: 39072214 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases