Cellular factors in the transcription and replication of viral RNA genomes: a parallel to DNA-dependent RNA transcription - PubMed (original) (raw)
Review
. 1998 Apr 25;244(1):1-12.
doi: 10.1006/viro.1998.9098.
Affiliations
- PMID: 9581772
- DOI: 10.1006/viro.1998.9098
Free article
Review
Cellular factors in the transcription and replication of viral RNA genomes: a parallel to DNA-dependent RNA transcription
M M Lai. Virology. 1998.
Free article
Abstract
Viral RNA replication and transcription involves not only viral RNA-dependent RNA polymerases, but also cellular proteins, the majority of which are subverted from the RNA-processing or translation machineries of host cells. These factors interact with viral RNA or polymerases to form transcription or replication ribonucleoprotein complexes and may provide template specificity for RNA-dependent RNA synthesis, suggesting a close parallel to the mechanism of DNA-dependent RNA synthesis. The types of cellular proteins involved and their modes of action are reviewed.