Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest - PubMed (original) (raw)
Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest
L Smith et al. Nat Genet. 1998 May.
Abstract
Chromosome 3q alterations occur frequently in many types of tumours. In a genetic screen for loci present in rhabdomyosarcomas, we identified an isochromosome 3q [i(3q)], which inhibits muscle differentiation when transferred into myoblasts. The i(3q) inhibits MyoD function, resulting in a non-differentiating phenotype. Furthermore, the i(3q) induces a 'cut' phenotype, abnormal centrosome amplification, aneuploidy and loss of G1 arrest following gamma-irradiation. Testing candidate genes within this region reveals that forced expression of ataxia-telangiectasia and rad3-related (ATR) results in a phenocopy of the i(3q). Thus, genetic alteration of ATR leads to loss of differentiation as well as cell-cycle abnormalities.
Comment in
- Sibling rivalry, arrested development and chromosomal mayhem.
Friend SH, Tapscott SJ. Friend SH, et al. Nat Genet. 1998 May;19(1):9-10. doi: 10.1038/ng0598-9. Nat Genet. 1998. PMID: 9590278 No abstract available.
Similar articles
- [New insight into MyoD regulation: involvement in rhabdomyosarcoma pathway?].
Tintignac LA, Leibovitch MP, Leibovitch SA. Tintignac LA, et al. Bull Cancer. 2001 Jun;88(6):545-8. Bull Cancer. 2001. PMID: 11459700 Review. French. - Mutation of Thr115 in MyoD positively regulates function in murine fibroblasts and human rhabdomyosarcoma cells.
Liu LN, Dias P, Houghton PJ. Liu LN, et al. Cell Growth Differ. 1998 Sep;9(9):699-711. Cell Growth Differ. 1998. PMID: 9751114 - p21WAF1 expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells.
Ciccarelli C, Marampon F, Scoglio A, Mauro A, Giacinti C, De Cesaris P, Zani BM. Ciccarelli C, et al. Mol Cancer. 2005 Dec 13;4:41. doi: 10.1186/1476-4598-4-41. Mol Cancer. 2005. PMID: 16351709 Free PMC article. - Amplification of MDM2 inhibits MyoD-mediated myogenesis.
Fiddler TA, Smith L, Tapscott SJ, Thayer MJ. Fiddler TA, et al. Mol Cell Biol. 1996 Sep;16(9):5048-57. doi: 10.1128/MCB.16.9.5048. Mol Cell Biol. 1996. PMID: 8756663 Free PMC article. - The conceptual bases for the phenotypic mapping of conditions resulting from aneuploidy.
Epstein CJ. Epstein CJ. Prog Clin Biol Res. 1993;384:1-18. Prog Clin Biol Res. 1993. PMID: 8115397 Review. No abstract available.
Cited by
- Genomic and epigenetic instability in colorectal cancer pathogenesis.
Grady WM, Carethers JM. Grady WM, et al. Gastroenterology. 2008 Oct;135(4):1079-99. doi: 10.1053/j.gastro.2008.07.076. Epub 2008 Sep 4. Gastroenterology. 2008. PMID: 18773902 Free PMC article. Review. - Chromosomal Instability in Gastric Cancer Biology.
Maleki SS, Röcken C. Maleki SS, et al. Neoplasia. 2017 May;19(5):412-420. doi: 10.1016/j.neo.2017.02.012. Epub 2017 Apr 18. Neoplasia. 2017. PMID: 28431273 Free PMC article. Review. - Autozygosity mapping of a seckel syndrome locus to chromosome 3q22. 1-q24.
Goodship J, Gill H, Carter J, Jackson A, Splitt M, Wright M. Goodship J, et al. Am J Hum Genet. 2000 Aug;67(2):498-503. doi: 10.1086/303023. Epub 2000 Jul 11. Am J Hum Genet. 2000. PMID: 10889046 Free PMC article. - When 2+2=5: the origins and fates of aneuploid and tetraploid cells.
King RW. King RW. Biochim Biophys Acta. 2008 Sep;1786(1):4-14. doi: 10.1016/j.bbcan.2008.07.007. Epub 2008 Aug 7. Biochim Biophys Acta. 2008. PMID: 18703117 Free PMC article. Review. - Hzf, a p53-responsive gene, regulates maintenance of the G2 phase checkpoint induced by DNA damage.
Sugimoto M, Gromley A, Sherr CJ. Sugimoto M, et al. Mol Cell Biol. 2006 Jan;26(2):502-12. doi: 10.1128/MCB.26.2.502-512.2006. Mol Cell Biol. 2006. PMID: 16382142 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous