Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo - PubMed (original) (raw)
Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo
I B Weinstein et al. Science. 1976.
Abstract
Evidence has been obtained that a specific isomer of a diol epoxide derivative of benzo(a)pyrene, (+/-)-7 beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene, is an intermediate in the binding of benzo(a)pyrene to RNA in cultured bovine bronchial mucosa. An adduct is formed between position 10 of this derivative and the 2-amino group of guanine.
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