Genomic structure of Unp, a murine gene encoding a ubiquitin-specific protease - PubMed (original) (raw)
Genomic structure of Unp, a murine gene encoding a ubiquitin-specific protease
M Di Fruscio et al. Biochim Biophys Acta. 1998.
Abstract
The murine Unp gene encodes a ubiquitin-specific protease, a member of a family of enzymes that includes the product of the human tre-2 oncogene. The Unp gene has previously been mapped to chromosome 9. We have cloned in bacteriophage a 50 kilobase region of chromosome 9 containing the Unp gene, and have determined the nucleotide sequence of the gene. The gene has 22 exons, distributed over 47.4 kb. A processed ribosomal S2 pseudogene was identified in the third intron of the Unp gene. Expression of Unp is driven by a GC-rich, 'housekeeping' type promoter.
Copyright 1998 Elsevier Science B.V. All rights reserved.
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