Enhancing immune responses using suicidal DNA vaccines - PubMed (original) (raw)

Comparative Study

doi: 10.1038/nbt0698-562.

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• PMID: 9624688
• DOI: 10.1038/nbt0698-562

Comparative Study

Enhancing immune responses using suicidal DNA vaccines

P Berglund et al. Nat Biotechnol. 1998 Jun.

Abstract

We describe a DNA vaccine strategy that allows antigens to be produced in vivo in the context of an alphaviral replicon. Mice immunized with such vectors developed humoral and cellular immune responses at higher levels than mice that received a conventional DNA vaccine vector. Immunized animals acquired protective immunity to lethal influenza challenge. Compared with traditional DNA vaccine strategies in which vectors are persistent and the expression constitutive, the expression mediated by the alphaviral vector was transient and lytic. As a result, biosafety risks such as chromosomal integration, and the induction of immunological tolerance, could be circumvented.

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Comment in

• DNA vaccines with a kick.
  Polo JM, Dubensky TW Jr. Polo JM, et al. Nat Biotechnol. 1998 Jun;16(6):517-8. doi: 10.1038/nbt0698-517. Nat Biotechnol. 1998. PMID: 9624677 No abstract available.

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