Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses - PubMed (original) (raw)

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

S Teglund et al. Cell. 1998.

Free article

Abstract

A variety of cytokines mediate the activation of Janus protein tyrosine kinases (Jaks). The Jaks then phosphorylate cellular substrates, including members of the signal transducers and activators of transcription (Stat) family of transcription factors. Among the Stats, the two highly related proteins, Stat5a and Stat5b, are activated by a variety of cytokines. To assess the role of the Stat5 proteins, mutant mice were derived that have the genes deleted individually or together. The phenotypes of the mice demonstrate an essential, and often redundant, role for the two Stat5 proteins in a spectrum of physiological responses associated with growth hormone and prolactin. Conversely, the responses to a variety of cytokines that activate the Stat5 proteins, including erythropoietin, are largely unaffected.

PubMed Disclaimer

Cited by

Pro-inflammatory signals induce 20α-HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal.
Nadeem L, Balendran R, Dorogin A, Mesiano S, Shynlova O, Lye SJ. Nadeem L, et al. J Cell Mol Med. 2021 Jul;25(14):6773-6785. doi: 10.1111/jcmm.16681. Epub 2021 Jun 10. J Cell Mol Med. 2021. PMID: 34114342 Free PMC article.
Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function.
Lin JX, Li P, Liu D, Jin HT, He J, Ata Ur Rasheed M, Rochman Y, Wang L, Cui K, Liu C, Kelsall BL, Ahmed R, Leonard WJ. Lin JX, et al. Immunity. 2012 Apr 20;36(4):586-99. doi: 10.1016/j.immuni.2012.02.017. Immunity. 2012. PMID: 22520852 Free PMC article.
Growth hormone receptor in dopaminergic neurones regulates stress-induced prolactin release in male mice.
Wasinski F, Chaves FM, Pedroso JAB, Mansano NS, Camporez JP, Gusmão DO, List EO, Kopchick JJ, Frazão R, Szawka RE, Donato J Jr. Wasinski F, et al. J Neuroendocrinol. 2021 Mar;33(3):e12957. doi: 10.1111/jne.12957. J Neuroendocrinol. 2021. PMID: 33769619 Free PMC article.
Neuronal STAT5 signaling is required for maintaining lactation but not for postpartum maternal behaviors in mice.
Buonfiglio DC, Ramos-Lobo AM, Silveira MA, Furigo IC, Hennighausen L, Frazão R, Donato J Jr. Buonfiglio DC, et al. Horm Behav. 2015 May;71:60-8. doi: 10.1016/j.yhbeh.2015.04.004. Epub 2015 Apr 17. Horm Behav. 2015. PMID: 25896118 Free PMC article.
SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.
Lindeman GJ, Wittlin S, Lada H, Naylor MJ, Santamaria M, Zhang JG, Starr R, Hilton DJ, Alexander WS, Ormandy CJ, Visvader J. Lindeman GJ, et al. Genes Dev. 2001 Jul 1;15(13):1631-6. doi: 10.1101/gad.880801. Genes Dev. 2001. PMID: 11445538 Free PMC article.

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses - PubMed (original) (raw)