ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis - PubMed (original) (raw)
Review
. 1996 Mar;14(3):297-301.
doi: 10.1038/nbt0396-297.
Affiliations
- PMID: 9630889
- DOI: 10.1038/nbt0396-297
Review
ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis
D W Nicholson. Nat Biotechnol. 1996 Mar.
Abstract
Excessive or failed apoptosis is a prominent morphological feature of several human diseases. Many of the key biochemical players that contribute to the highly ordered process of apoptotic cell death have recently been identified. These include members of the emerging family of cysteine proteases related to mammalian interleukin-1 beta converting enzyme (ICE) and to CED-3, the product of a gene that is necessary for programmed cell death in the nematode C. elegans. Among a growing number of potential molecular targets for the control of human diseases where inappropriate apoptosis is prominent, ICE/CED-3-like proteases may be an attractive and tangible point for therapeutic intervention.
Similar articles
- Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death.
Robertson NM, Zangrilli J, Fernandes-Alnemri T, Friesen PD, Litwack G, Alnemri ES. Robertson NM, et al. Cancer Res. 1997 Jan 1;57(1):43-7. Cancer Res. 1997. PMID: 8988038 - Peptidyl beta-homo-aspartals (3-amino-4-carboxybutyraldehydes): new specific inhibitors of caspases.
Bajusz S, Fauszt I, Németh K, Barabás E, Juhász A, Patthy M, Bauer PI. Bajusz S, et al. Biopolymers. 1999;51(1):109-18. doi: 10.1002/(SICI)1097-0282(1999)51:1<109::AID-BIP12>3.0.CO;2-S. Biopolymers. 1999. PMID: 10380358 - Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.
Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, et al. Nicholson DW, et al. Nature. 1995 Jul 6;376(6535):37-43. doi: 10.1038/376037a0. Nature. 1995. PMID: 7596430 - Execution mechanisms of programmed cell death by caspase (ICE/CED-3) family proteases.
Miura M, Hisahara S, Araki T, Okano H. Miura M, et al. Heart Vessels. 1997;Suppl 12:66-70. Heart Vessels. 1997. PMID: 9476547 Review. - [Ice/ced-3 family gene and apoptosis].
Miura M. Miura M. Nihon Rinsho. 1996 Jul;54(7):1860-8. Nihon Rinsho. 1996. PMID: 8741679 Review. Japanese.
Cited by
- Advances in the application of logic gates in nanozymes.
Hou X, Ga L, Zhang X, Ai J. Hou X, et al. Anal Bioanal Chem. 2024 Mar 15. doi: 10.1007/s00216-024-05240-w. Online ahead of print. Anal Bioanal Chem. 2024. PMID: 38488951 Review. - Prevotella histicola Mitigated Estrogen Deficiency-Induced Depression via Gut Microbiota-Dependent Modulation of Inflammation in Ovariectomized Mice.
Huang F, Liu X, Xu S, Hu S, Wang S, Shi D, Wang K, Wang Z, Lin Q, Li S, Zhao S, Jin K, Wang C, Chen L, Wang F. Huang F, et al. Front Nutr. 2022 Jan 26;8:805465. doi: 10.3389/fnut.2021.805465. eCollection 2021. Front Nutr. 2022. PMID: 35155523 Free PMC article. - Chronic Upregulation of Cleaved-Caspase-3 Associated with Chronic Myelin Pathology and Microvascular Reorganization in the Thalamus after Traumatic Brain Injury in Rats.
Glushakov AO, Glushakova OY, Korol TY, Acosta SA, Borlongan CV, Valadka AB, Hayes RL, Glushakov AV. Glushakov AO, et al. Int J Mol Sci. 2018 Oct 13;19(10):3151. doi: 10.3390/ijms19103151. Int J Mol Sci. 2018. PMID: 30322151 Free PMC article. - Uric acid promotes apoptosis in human proximal tubule cells by oxidative stress and the activation of NADPH oxidase NOX 4.
Verzola D, Ratto E, Villaggio B, Parodi EL, Pontremoli R, Garibotto G, Viazzi F. Verzola D, et al. PLoS One. 2014 Dec 16;9(12):e115210. doi: 10.1371/journal.pone.0115210. eCollection 2014. PLoS One. 2014. PMID: 25514209 Free PMC article. - Role of the CASP-9 Ex5+32 G>A polymorphism in susceptibility to cancer: A meta-analysis.
Yan S, Li YZ, Zhu XW, Liu CL, Wang P, Liu YL. Yan S, et al. Exp Ther Med. 2013 Jan;5(1):175-180. doi: 10.3892/etm.2012.756. Epub 2012 Oct 19. Exp Ther Med. 2013. PMID: 23251262 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources