Clinical features and prognostic implications of familial hypertrophic cardiomyopathy related to the cardiac myosin-binding protein C gene - PubMed (original) (raw)
. 1998 Jun 9;97(22):2230-6.
doi: 10.1161/01.cir.97.22.2230.
O Dubourg, M Desnos, M Bennaceur, L Carrier, A C Camproux, R Isnard, A Hagege, J M Langlard, G Bonne, P Richard, B Hainque, J B Bouhour, K Schwartz, M Komajda
Affiliations
- PMID: 9631872
- DOI: 10.1161/01.cir.97.22.2230
Clinical features and prognostic implications of familial hypertrophic cardiomyopathy related to the cardiac myosin-binding protein C gene
P Charron et al. Circulation. 1998.
Abstract
Background: Little information is available on phenotype-genotype correlations in familial hypertrophic cardiomyopathy that are related to the cardiac myosin binding protein C (MYBPC3) gene. The aim of this study was to perform this type of analysis.
Methods and results: We studied 76 genetically affected subjects from nine families with seven recently identified mutations (SASint20, SDSint7, SDSint23, branch point int23, Glu542Gln, a deletion in exon 25, and a duplication/deletion in exon 33) in the MYBPC3 gene. Detailed clinical, ECG, and echocardiographic parameters were analyzed. An intergene analysis was performed by comparing the MYBPC3 group to seven mutations in the beta-myosin heavy-chain gene (beta-MHC) group (n=52). There was no significant phenotypic difference among the different mutations in the MYBPC3 gene. However, in the MYBPC3 group compared with the beta-MHC group, (1) prognosis was significantly better (P<0.0001), and no deaths occurred before the age of 40 years; (2) the age at onset of symptoms was delayed (41+/-19 versus 35+/-17 years, P<0.002); and (3) before 30 years of age, the phenotype was particularly mild because penetrance was low (41% versus 62%), maximal wall thicknesses lower (12+/-4 versus 16+/-7 mm, P<0.03), and abnormal T waves less frequent (9% versus 45%, P<0.02).
Conclusions: These results are consistent with specific clinical features related to the MYBPC3 gene: onset of the disease appears delayed and the prognosis is better than that associated with the beta-MHC gene. These findings could be particularly important for the purpose of clinical management and genetic counseling in familial hypertrophic cardiomyopathy.
Comment in
- Clinical expression in patients with hypertrophic cardiomyopathy caused by cardiac myosin-binding protein C gene mutation.
Doi YL, Kitaoka H, Hitomi N, Satoh M, Kimura A. Doi YL, et al. Circulation. 1999 Jul 27;100(4):448-9. Circulation. 1999. PMID: 10447378 No abstract available.
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