p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13 - PubMed (original) (raw)
p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13
T Kozasa et al. Science. 1998.
Abstract
Members of the regulators of G protein signaling (RGS) family stimulate the intrinsic guanosine triphosphatase (GTPase) activity of the alpha subunits of certain heterotrimeric guanine nucleotide-binding proteins (G proteins). The guanine nucleotide exchange factor (GEF) for Rho, p115 RhoGEF, has an amino-terminal region with similarity to RGS proteins. Recombinant p115 RhoGEF and a fusion protein containing the amino terminus of p115 had specific activity as GTPase activating proteins toward the alpha subunits of the G proteins G12 and G13, but not toward members of the Gs, Gi, or Gq subfamilies of Galpha proteins. This GEF may act as an intermediary in the regulation of Rho proteins by G13 and G12.
Comment in
- G proteins and small GTPases: distant relatives keep in touch.
Hall A. Hall A. Science. 1998 Jun 26;280(5372):2074-5. doi: 10.1126/science.280.5372.2074. Science. 1998. PMID: 9669963 No abstract available.
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