In vivo expression of a TCR antagonist: T cells escape central tolerance but are antagonized in the periphery - PubMed (original) (raw)
Comparative Study
. 1998 Jul 1;161(1):128-37.
Affiliations
- PMID: 9647216
Comparative Study
In vivo expression of a TCR antagonist: T cells escape central tolerance but are antagonized in the periphery
C B Williams et al. J Immunol. 1998.
Abstract
Transgenic 3.L2 T cells are stimulated by Hb(64-76)/I-Ek and are positively selected on I-Ek plus self-peptides. To this pool of self-peptides we have added a single, well-defined 3.L2 TCR antagonist (A72) in vivo. We find that mice expressing both the 3.L2 TCR and A72 have a minimal loss of T cells expressing the clonotypic TCR in the thymus and spleen. Importantly, the proliferative response of 3.L2 x A72 splenocytes is significantly reduced compared with splenocytes from 3.L2 mice. This reduced response can be attributed to peripheral antagonism. Thus we have identified a new class of self-ligands whose predominant effect is constitutive peripheral antagonism rather than negative selection. The net effect of these ligands is to avoid potential self-reactivity while maintaining as large a repertoire as possible.
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