Transducing Hedgehog: the story so far - PubMed (original) (raw)
Review
Transducing Hedgehog: the story so far
P W Ingham. EMBO J. 1998.
Abstract
The secreted proteins of the Hedgehog family have been implicated in many different processes in vertebrate development including cartilage differentiation, myotome and sclerotome specification, hair follicle development, limb morphogenesis and the specification of different neuronal cell types. In addition, the aberrant activation of the Hedgehog pathway has been identified as the likely cause of a number of tumours in humans including basal cell carcinomas (BCCs) and primitive neurectodermal tumours (PNETs). Elucidating the mechanisms by which Hedgehog signals are transduced will thus have widespread implications for our understanding of both normal development and disease.
Similar articles
- Hedgehog signal transduction: from flies to vertebrates.
Murone M, Rosenthal A, de Sauvage FJ. Murone M, et al. Exp Cell Res. 1999 Nov 25;253(1):25-33. doi: 10.1006/excr.1999.4676. Exp Cell Res. 1999. PMID: 10579908 Review. - Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened.
Denef N, Neubüser D, Perez L, Cohen SM. Denef N, et al. Cell. 2000 Aug 18;102(4):521-31. doi: 10.1016/s0092-8674(00)00056-8. Cell. 2000. PMID: 10966113 - Hedgehog signalling: pulling apart patched and smoothened.
Stark DR. Stark DR. Curr Biol. 2002 Jun 25;12(12):R437-9. doi: 10.1016/s0960-9822(02)00920-x. Curr Biol. 2002. PMID: 12123598 - The hedgehog signalling pathway in tumorigenesis and development.
Wicking C, Smyth I, Bale A. Wicking C, et al. Oncogene. 1999 Dec 20;18(55):7844-51. doi: 10.1038/sj.onc.1203282. Oncogene. 1999. PMID: 10630637 Review. - The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog.
Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, Scott MP, Pennica D, Goddard A, Phillips H, Noll M, Hooper JE, de Sauvage F, Rosenthal A. Stone DM, et al. Nature. 1996 Nov 14;384(6605):129-34. doi: 10.1038/384129a0. Nature. 1996. PMID: 8906787
Cited by
- The transcriptional repressor Glis2 is a novel binding partner for p120 catenin.
Hosking CR, Ulloa F, Hogan C, Ferber EC, Figueroa A, Gevaert K, Birchmeier W, Briscoe J, Fujita Y. Hosking CR, et al. Mol Biol Cell. 2007 May;18(5):1918-27. doi: 10.1091/mbc.e06-10-0941. Epub 2007 Mar 7. Mol Biol Cell. 2007. PMID: 17344476 Free PMC article. - Activation of the hedgehog pathway in advanced prostate cancer.
Sheng T, Li C, Zhang X, Chi S, He N, Chen K, McCormick F, Gatalica Z, Xie J. Sheng T, et al. Mol Cancer. 2004 Oct 13;3:29. doi: 10.1186/1476-4598-3-29. Mol Cancer. 2004. PMID: 15482598 Free PMC article. - Ambient pH signaling regulates nuclear localization of the Aspergillus nidulans PacC transcription factor.
Mingot JM, Espeso EA, Díez E, Peñalva MA. Mingot JM, et al. Mol Cell Biol. 2001 Mar;21(5):1688-99. doi: 10.1128/MCB.21.5.1688-1699.2001. Mol Cell Biol. 2001. PMID: 11238906 Free PMC article. - Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.
Monnier V, Ho KS, Sanial M, Scott MP, Plessis A. Monnier V, et al. BMC Dev Biol. 2002 Mar 19;2:4. doi: 10.1186/1471-213x-2-4. BMC Dev Biol. 2002. PMID: 11914126 Free PMC article. - Naringin promotes osteogenic differentiation of bone marrow stromal cells by up-regulating Foxc2 expression via the IHH signaling pathway.
Lin FX, Du SX, Liu DZ, Hu QX, Yu GY, Wu CC, Zheng GZ, Xie D, Li XD, Chang B. Lin FX, et al. Am J Transl Res. 2016 Nov 15;8(11):5098-5107. eCollection 2016. Am J Transl Res. 2016. PMID: 27904711 Free PMC article.
References
- Genes Dev. 1996 Feb 1;10(3):301-12 - PubMed
- Development. 1996 Apr;122(4):1225-33 - PubMed
- Science. 1996 Jun 14;272(5268):1621-5 - PubMed
- Science. 1996 Jun 14;272(5268):1668-71 - PubMed
- Cell. 1996 Jun 14;85(6):841-51 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases