The combined role of P- and E-selectins in atherosclerosis - PubMed (original) (raw)
The combined role of P- and E-selectins in atherosclerosis
Z M Dong et al. J Clin Invest. 1998.
Abstract
P- and E-selectins are adhesion molecules mediating the first step in leukocyte extravasation. Because their function in leukocyte adhesion is overlapping, we hypothesized that there might be a combined effect of these selectins on the development of atherosclerotic lesions. We bred P- and E-selectin-double-deficient mice onto the low-density lipoprotein receptor (LDLR)-deficient background (LDLR-/- P/E-/-) and compared lesion development in these mice to that in mice wild type for both selectins (LDLR-/- P/E+/+). After 8 wk on atherogenic diet, the LDLR-/- P/E-/- mice developed fatty streaks in the aortic sinus that were five times smaller than those in LDLR-/- P/E+/+ mice. The density of macrophages in the fatty streaks was comparable between LDLR-/- P/E+/+ and LDLR-/- P/E-/- mice. After 22 wk on the diet, the lesions spread throughout the aorta but this process was delayed in LDLR-/- P/E-/- mice. At 37 wk on diet, the lesions progressed to the fibrous plaque stage in both genotypes. However, the lesions in the aortic sinus in LDLR-/- P/E-/- mice were 40% smaller and less calcified than those of LDLR-/- P/E +/+ mice. Our results suggest that P- and E-selectins together play an important role in both early and advanced stages of atherosclerotic lesion development.
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References
- Annu Rev Med. 1994;45:361-78 - PubMed
- Arterioscler Thromb Vasc Biol. 1997 Aug;17(8):1517-20 - PubMed
- Blood. 1994 Oct 1;84(7):2068-101 - PubMed
- J Immunol Methods. 1994 Sep 30;175(1):47-58 - PubMed
- Cell. 1995 Feb 10;80(3):413-22 - PubMed