Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex - PubMed (original) (raw)
Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex
S Iwata et al. Science. 1998.
Abstract
Mitochondrial cytochrome bc1 complex performs two functions: It is a respiratory multienzyme complex and it recognizes a mitochondrial targeting presequence. Refined crystal structures of the 11-subunit bc1 complex from bovine heart reveal full views of this bifunctional enzyme. The "Rieske" iron-sulfur protein subunit shows significant conformational changes in different crystal forms, suggesting a new electron transport mechanism of the enzyme. The mitochondrial targeting presequence of the "Rieske" protein (subunit 9) is lodged between the two "core" subunits at the matrix side of the complex. These "core" subunits are related to the matrix processing peptidase, and the structure unveils how mitochondrial targeting presequences are recognized.
Comment in
- Secret life of cytochrome bc1.
Smith JL. Smith JL. Science. 1998 Jul 3;281(5373):58-9. doi: 10.1126/science.281.5373.58. Science. 1998. PMID: 9679019 No abstract available.
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