Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes - PubMed (original) (raw)
Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes
F Crawford et al. Immunity. 1998 Jun.
Free article
Abstract
Multimeric soluble MHC class II molecules stably occupied with covalently attached peptides bind with appropriate specificity to T cell hybridomas and T cells from T cell receptor transgenic mice. There is a direct correlation between soluble T cell receptor affinity for monomeric MHC/peptide and level of binding of multimeric MHC/peptide to T cells. While binding of the multimeric MHC/peptide complex is proportional to T cell receptor affinity and expression level, there is little influence of T cell CD4.
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