Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes - PubMed (original) (raw)
Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes
L Sun et al. Immunity. 1998 Jun.
Free article
Abstract
Calcineurin plays a pivotal role in the T cell receptor (TCR)-mediated signal transduction pathway and serves as a common target for the immunosuppressants FK506 and cyclosporin A. We report the identification of a novel endogenous calcineurin binding protein named Cabin 1 that inhibits calcineurin-mediated signal transduction. The interaction between Cabin 1 and calcineurin is dependent on PKC activation. Overexpression of Cabin 1 or its N-terminal truncation mutants inhibits the transcriptional activation of calcineurin-responsive elements in the interleukin-2 promoter and blocks dephosphorylation of NF-AT upon T cell activation. These results suggest a negative regulatory role for Cabin 1 in calcineurin signaling and provide a possible mechanism of feedback inhibition of TCR signaling through cross-talk between protein kinases and calcineurin.
Similar articles
- Regulation of cell surface expression of Fas (CD95) ligand and susceptibility to Fas (CD95)-mediated apoptosis in activation-induced T cell death involves calcineurin and protein kinase C, respectively.
Tóth R, Szegezdi E, Molnár G, Lord JM, Fésüs L, Szondy Z. Tóth R, et al. Eur J Immunol. 1999 Feb;29(2):383-93. doi: 10.1002/(SICI)1521-4141(199902)29:02<383::AID-IMMU383>3.0.CO;2-A. Eur J Immunol. 1999. PMID: 10064053 - Calcineurin mutants render T lymphocytes resistant to cyclosporin A.
Zhu D, Cardenas ME, Heitman J. Zhu D, et al. Mol Pharmacol. 1996 Sep;50(3):506-11. Mol Pharmacol. 1996. PMID: 8794888 - FK506 and cyclosporin, molecular probes for studying intracellular signal transduction.
Liu J. Liu J. Immunol Today. 1993 Jun;14(6):290-5. doi: 10.1016/0167-5699(93)90048-P. Immunol Today. 1993. PMID: 7691065 Review. - The role of calcineurin in lymphocyte activation.
Baksh S, Burakoff SJ. Baksh S, et al. Semin Immunol. 2000 Aug;12(4):405-15. doi: 10.1006/smim.2000.0221. Semin Immunol. 2000. PMID: 10995587 Review.
Cited by
- Differential regulation of the histone chaperone HIRA during muscle cell differentiation by a phosphorylation switch.
Yang JH, Song TY, Jo C, Park J, Lee HY, Song I, Hong S, Jung KY, Kim J, Han JW, Youn HD, Cho EJ. Yang JH, et al. Exp Mol Med. 2016 Aug 12;48(8):e252. doi: 10.1038/emm.2016.68. Exp Mol Med. 2016. PMID: 27515126 Free PMC article. - Decoding the Phosphatase Code: Regulation of Cell Proliferation by Calcineurin.
Masaki T, Shimada M. Masaki T, et al. Int J Mol Sci. 2022 Jan 20;23(3):1122. doi: 10.3390/ijms23031122. Int J Mol Sci. 2022. PMID: 35163061 Free PMC article. Review. - Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3.
Ohteki T, Parsons M, Zakarian A, Jones RG, Nguyen LT, Woodgett JR, Ohashi PS. Ohteki T, et al. J Exp Med. 2000 Jul 3;192(1):99-104. doi: 10.1084/jem.192.1.99. J Exp Med. 2000. PMID: 10880530 Free PMC article. - Calcineurin inactivation inhibits pyruvate dehydrogenase complex activity and induces the Warburg effect.
Zhang J, Zhang L, Nie J, Lin Y, Li Y, Xu W, Zhao JY, Zhao SM, Wang C. Zhang J, et al. Oncogene. 2021 Dec;40(49):6692-6702. doi: 10.1038/s41388-021-02065-0. Epub 2021 Oct 19. Oncogene. 2021. PMID: 34667275 - A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression.
Delling U, Tureckova J, Lim HW, De Windt LJ, Rotwein P, Molkentin JD. Delling U, et al. Mol Cell Biol. 2000 Sep;20(17):6600-11. doi: 10.1128/MCB.20.17.6600-6611.2000. Mol Cell Biol. 2000. PMID: 10938134 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases