Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium - PubMed (original) (raw)
. 1998 Jul 10;81(4):290-5.
T Matise, D Svrakic, J Pepple, D Malaspina, B Suarez, C Hampe, C T Zambuto, K Schmitt, J Meyer, P Markel, H Lee, J Harkavy Friedman, C Kaufmann, C R Cloninger, M T Tsuang
Affiliations
- PMID: 9674973
Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium
S V Faraone et al. Am J Med Genet. 1998.
Abstract
The Genetics Initiative of the National Institute of Mental Health (NIMH) was a multisite study that created a national repository of DNA from families informative for genetic linkage studies of schizophrenia, bipolar disorder, and Alzheimer's disease. The schizophrenia families were collected by three sites: Washington University, Harvard University, and Columbia University. This article, one in a series that describes the data collected for linkage analysis by the schizophrenia consortium, presents the results for the European-American sample. The European-American sample comprised 43 nuclear families and 146 subjects. Ninety-six of the family members were considered affected by virtue of having received a DSM-III-R diagnosis of schizophrenia (N = 82) or schizoaffective disorder, depressed (N = 14). The families contained a total of 50 independent sib-pairs. Using the significance threshold criteria suggested by Lander and Kruglyak [(1995): Nat Genet 241-247], no region showed statistically significant evidence for linkage; two markers on chromosome 10p showed statistical evidence suggestive of linkage using the criteria of Lander and Kruglyak [(1995): Nat Genet 241-247]: D10S1423 (nonparametric linkage (NPL) Z = 3.4, P = .0004) and its neighbor, D10S582 (NPL Z = 3.2, P = .0006).
Similar articles
- NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees.
Kaufmann CA, Suarez B, Malaspina D, Pepple J, Svrakic D, Markel PD, Meyer J, Zambuto CT, Schmitt K, Matise TC, Harkavy Friedman JM, Hampe C, Lee H, Shore D, Wynne D, Faraone SV, Tsuang MT, Cloninger CR. Kaufmann CA, et al. Am J Med Genet. 1998 Jul 10;81(4):282-9. Am J Med Genet. 1998. PMID: 9674972 - Suggestive linkage of chromosome 10p to schizophrenia is not due to transmission ratio distortion.
Faraone SV, Meyer J, Matise T, Svrakic D, Pepple J, Malaspina D, Suarez B, Hampe C, Chan G, Aelony A, Friedman JH, Kaufmann C, Cloninger CR, Tsuang MT. Faraone SV, et al. Am J Med Genet. 1999 Dec 15;88(6):607-8. doi: 10.1002/(sici)1096-8628(19991215)88:6<607::aid-ajmg6>3.0.co;2-q. Am J Med Genet. 1999. PMID: 10581477 - Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample.
Suarez BK, Duan J, Sanders AR, Hinrichs AL, Jin CH, Hou C, Buccola NG, Hale N, Weilbaecher AN, Nertney DA, Olincy A, Green S, Schaffer AW, Smith CJ, Hannah DE, Rice JP, Cox NJ, Martinez M, Mowry BJ, Amin F, Silverman JM, Black DW, Byerley WF, Crowe RR, Freedman R, Cloninger CR, Levinson DF, Gejman PV. Suarez BK, et al. Am J Hum Genet. 2006 Feb;78(2):315-33. doi: 10.1086/500272. Epub 2006 Jan 3. Am J Hum Genet. 2006. PMID: 16400611 Free PMC article. - Further evidence for a susceptibility locus on chromosome 10p14-p11 in 72 families with schizophrenia by nonparametric linkage analysis.
Schwab SG, Hallmayer J, Albus M, Lerer B, Hanses C, Kanyas K, Segman R, Borrman M, Dreikorn B, Lichtermann D, Rietschel M, Trixler M, Maier W, Wildenauer DB. Schwab SG, et al. Am J Med Genet. 1998 Jul 10;81(4):302-7. Am J Med Genet. 1998. PMID: 9674975 - Genome-wide search for schizophrenia susceptibility loci: the NIMH Genetics Initiative and Millennium Consortium.
Cloninger CR, Kaufmann CA, Faraone SV, Malaspina D, Svrakic DM, Harkavy-Friedman J, Suarez BK, Matise TC, Shore D, Lee H, Hampe CL, Wynne D, Drain C, Markel PD, Zambuto CT, Schmitt K, Tsuang MT. Cloninger CR, et al. Am J Med Genet. 1998 Jul 10;81(4):275-81. Am J Med Genet. 1998. PMID: 9674971
Cited by
- Evaluation of polymorphism, hypermethylation and expression pattern of CTLA4 gene in a sample of Iranian patients with schizophrenia.
Kordi-Tamandani DM, Vaziri S, Dahmardeh N, Torkamanzehi A. Kordi-Tamandani DM, et al. Mol Biol Rep. 2013 Aug;40(8):5123-8. doi: 10.1007/s11033-013-2614-3. Epub 2013 May 11. Mol Biol Rep. 2013. PMID: 23666060 - The common genetic liability between schizophrenia and bipolar disorder: a review.
Bramon E, Sham PC. Bramon E, et al. Curr Psychiatry Rep. 2001 Aug;3(4):332-7. doi: 10.1007/s11920-001-0030-1. Curr Psychiatry Rep. 2001. PMID: 11470041 Review. - Bipolar disorder and schizophrenia: not so distant relatives?
Berrettini W. Berrettini W. World Psychiatry. 2003 Jun;2(2):68-72. World Psychiatry. 2003. PMID: 16946898 Free PMC article. - Linkage of familial schizophrenia to chromosome 13q32.
Brzustowicz LM, Honer WG, Chow EW, Little D, Hogan J, Hodgkinson K, Bassett AS. Brzustowicz LM, et al. Am J Hum Genet. 1999 Oct;65(4):1096-103. doi: 10.1086/302579. Am J Hum Genet. 1999. PMID: 10486329 Free PMC article. - Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23.
Gurling HM, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS, Read T, Murphy P, Blaveri E, McQuillin A, Petursson H, Curtis D. Gurling HM, et al. Am J Hum Genet. 2001 Mar;68(3):661-73. doi: 10.1086/318788. Am J Hum Genet. 2001. PMID: 11179014 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical