G protein-coupled receptor kinase 2 (GRK2): mechanisms of regulation and physiological functions - PubMed (original) (raw)
Review
. 1998 Jun 23;430(1-2):37-40.
doi: 10.1016/s0014-5793(98)00495-5.
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- PMID: 9678590
- DOI: 10.1016/s0014-5793(98)00495-5
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Review
G protein-coupled receptor kinase 2 (GRK2): mechanisms of regulation and physiological functions
A M Aragay et al. FEBS Lett. 1998.
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Abstract
G protein-coupled receptor kinase 2 (GRK2) plays a key role in determining the rate and extent of G protein-coupled receptor (GPCR) desensitization and resensitization. Recent data indicate that GRK2 activity, subcellular distribution and expression are tightly regulated. The important physiological function of GRK2 as a modulator of the efficacy of GPCR signal transduction systems is exemplified by its relevance in cardiovascular physiopathology as well as by its emerging role in the regulation of chemokine receptors.
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