Licochalcone A: an inducer of cell differentiation and cytotoxic agent from Pogostemon cablin - PubMed (original) (raw)
Licochalcone A: an inducer of cell differentiation and cytotoxic agent from Pogostemon cablin
E J Park et al. Planta Med. 1998 Jun.
Abstract
Licochalcone A (1), ombuin (2), and 5,7-dihydroxy-3',4'-dimethoxyflavanone (3) were isolated from the aerial parts of Pogostemon cablin by cytotoxicity-guided fractionation. Compound 1 showed in vitro cytotoxicity and Pl-PLC gamma 1 inhibition activity. Treatment of promyelocytic leukemia cells (HL-60) with compound 1 induced terminal differentiation with the generation of monocyte using nonspecific acid esterase assay.
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