lunatic fringe is an essential mediator of somite segmentation and patterning - PubMed (original) (raw)
. 1998 Jul 23;394(6691):377-81.
doi: 10.1038/28632.
Affiliations
- PMID: 9690473
- DOI: 10.1038/28632
lunatic fringe is an essential mediator of somite segmentation and patterning
Y A Evrard et al. Nature. 1998.
Abstract
The gene lunatic fringe encodes a secreted factor with significant sequence similarity to the Drosophila gene fringe. fringe has been proposed to function as a boundary-specific signalling molecule in the wing imaginal disc, where it is required to localize signalling activity by the protein Notch to the presumptive wing margin. By targeted disruption in mouse embryos, we show here that lunatic fringe is likewise required for boundary formation. lunatic fringe mutants fail to form boundaries between individual somites, the initial segmental unit of the vertebrate trunk. In addition, the normal alternating rostral-caudal pattern of the somitic mesoderm is disrupted, suggesting that intersomitic boundary formation and rostral-caudal patterning of somites are mechanistically linked by a process that requires lunatic fringe activity. As a result, the derivatives of the somitic mesoderm, especially the axial skeleton, are severely disorganized in lunatic fringe mutants. Taken together, our results demonstrate an essential function for a vertebrate fringe homologue and suggest a model in which lunatic fringe modulates Notch signalling in the segmental plate to regulate somitogenesis and rostral-caudal patterning of somites simultaneously.
Similar articles
- Defects in somite formation in lunatic fringe-deficient mice.
Zhang N, Gridley T. Zhang N, et al. Nature. 1998 Jul 23;394(6691):374-7. doi: 10.1038/28625. Nature. 1998. PMID: 9690472 - The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite.
Oginuma M, Takahashi Y, Kitajima S, Kiso M, Kanno J, Kimura A, Saga Y. Oginuma M, et al. Development. 2010 May;137(9):1515-22. doi: 10.1242/dev.044545. Epub 2010 Mar 24. Development. 2010. PMID: 20335362 - Vertebrate segmentation: the clock is linked to Notch signalling.
Jiang YJ, Smithers L, Lewis J. Jiang YJ, et al. Curr Biol. 1998 Dec 3;8(24):R868-71. doi: 10.1016/s0960-9822(07)00547-7. Curr Biol. 1998. PMID: 9843676 Review. - Disruption of the somitic molecular clock causes abnormal vertebral segmentation.
Sparrow DB, Chapman G, Turnpenny PD, Dunwoodie SL. Sparrow DB, et al. Birth Defects Res C Embryo Today. 2007 Jun;81(2):93-110. doi: 10.1002/bdrc.20093. Birth Defects Res C Embryo Today. 2007. PMID: 17600782 Review.
Cited by
- Cellular and molecular control of vertebrate somitogenesis.
Miao Y, Pourquié O. Miao Y, et al. Nat Rev Mol Cell Biol. 2024 Jul;25(7):517-533. doi: 10.1038/s41580-024-00709-z. Epub 2024 Feb 28. Nat Rev Mol Cell Biol. 2024. PMID: 38418851 Review. - In vivo evidence for GDP-fucose transport in the absence of transporter SLC35C1 and putative transporter SLC35C2.
Lu L, Varshney S, Yuan Y, Wei HX, Tanwar A, Sundaram S, Nauman M, Haltiwanger RS, Stanley P. Lu L, et al. J Biol Chem. 2023 Dec;299(12):105406. doi: 10.1016/j.jbc.2023.105406. Epub 2023 Oct 28. J Biol Chem. 2023. PMID: 38270391 Free PMC article. - Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations.
Shapiro F, Wang J, Flynn E, Wu JY. Shapiro F, et al. Biol Open. 2024 Jan 15;13(1):bio060139. doi: 10.1242/bio.060139. Epub 2024 Jan 22. Biol Open. 2024. PMID: 38252118 Free PMC article. - Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions.
Chen Y, Li H, Yi TC, Shen J, Zhang J. Chen Y, et al. Int J Mol Sci. 2023 Sep 13;24(18):14028. doi: 10.3390/ijms241814028. Int J Mol Sci. 2023. PMID: 37762331 Free PMC article. Review. - Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis.
Saito S, Mizumoto S, Yonekura T, Yamashita R, Nakano K, Okubo T, Yamada S, Okamura T, Furuichi T. Saito S, et al. PLoS One. 2023 Apr 13;18(4):e0284292. doi: 10.1371/journal.pone.0284292. eCollection 2023. PLoS One. 2023. PMID: 37053259 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials