Prognostic significance of neuroendocrine differentiation in clinically localized prostatic carcinoma - PubMed (original) (raw)
Affiliations
- PMID: 9690662
Prognostic significance of neuroendocrine differentiation in clinically localized prostatic carcinoma
P A Abrahamsson et al. Prostate Suppl. 1998.
Abstract
Several recent studies have focused attention on neuroendocrine differentiation (NED) in prostatic carcinoma (PC). Clinical studies have shown PC with NED to behave aggressively and to be associated with poor prognosis. To evaluate NED as an independent prognostic factor, we conducted a retrospective study of 87 patients with clinically localized PC who underwent radical prostatectomy. The presence of neuroendocrine tumor cells was confirmed by positive immunostaining for serotonin, chromogranin A, and neuron-specific enolase. The correlation between NED and disease progression was assessed. Progression of cancer was demonstrated in 35 (40%) of the patients. The presence of NED was confirmed in 60 (69%) of cases, and of these patients 26 (43%) manifested evidence of disease progression. Disease progression was also manifest in nine (33%) of the 27 patients without evidence of NED. Thus, in the setting of clinically localized carcinoma of the prostate, NED does not appear to be a statistically significant independent prognostic factor.
Similar articles
- Prognostic significance of proliferation activity and neuroendocrine differentiation to predict treatment failure after radical prostatectomy.
May M, Siegsmund M, Hammermann F, Loy V, Gunia S. May M, et al. Scand J Urol Nephrol. 2007;41(5):375-81. doi: 10.1080/00365590701224445. Epub 2007 Jul 27. Scand J Urol Nephrol. 2007. PMID: 17853019 - Evaluation and clinical value of neuroendocrine differentiation in human prostatic tumors.
Cussenot O, Villette JM, Cochand-Priollet B, Berthon P. Cussenot O, et al. Prostate Suppl. 1998;8:43-51. Prostate Suppl. 1998. PMID: 9690663 Review. - Evaluation of neuroendocrine staining and androgen receptor expression in incidental prostatic adenocarcinoma: prognostic implications.
Theodoropoulos VE, Tsigka A, Mihalopoulou A, Tsoukala V, Lazaris AC, Patsouris E, Ghikonti I. Theodoropoulos VE, et al. Urology. 2005 Oct;66(4):897-902. doi: 10.1016/j.urology.2005.04.064. Urology. 2005. PMID: 16230178 - Lymphovascular invasion is an independent prognostic factor in prostatic adenocarcinoma.
Cheng L, Jones TD, Lin H, Eble JN, Zeng G, Carr MD, Koch MO. Cheng L, et al. J Urol. 2005 Dec;174(6):2181-5. doi: 10.1097/01.ju.0000181215.41607.c3. J Urol. 2005. PMID: 16280760 - Divergent neuroendocrine differentiation in prostatic carcinoma.
di Sant' Agnese PA. di Sant' Agnese PA. Semin Diagn Pathol. 2000 May;17(2):149-61. Semin Diagn Pathol. 2000. PMID: 10839615 Review.
Cited by
- PET radiotracers for whole-body in vivo molecular imaging of prostatic neuroendocrine malignancies.
Cohen D, Hazut Krauthammer S, Fahoum I, Kesler M, Even-Sapir E. Cohen D, et al. Eur Radiol. 2023 Sep;33(9):6502-6512. doi: 10.1007/s00330-023-09619-8. Epub 2023 Apr 13. Eur Radiol. 2023. PMID: 37052659 Review. - Deciphering the enigma of neuroendocrine prostate cancer.
Karzai F, Madan RA. Karzai F, et al. J Clin Invest. 2022 Nov 1;132(21):e164611. doi: 10.1172/JCI164611. J Clin Invest. 2022. PMID: 36317631 Free PMC article. - Neuroendocrine differentiation in the setting of prostatic carcinoma: contemporary assessment of a consecutive series.
Gopalan A, Al-Ahmadie H, Chen YB, Sarungbam J, Sirintrapun SJ, Tickoo SK, Reuter VE, Fine SW. Gopalan A, et al. Histopathology. 2022 Aug;81(2):246-254. doi: 10.1111/his.14707. Epub 2022 Jul 11. Histopathology. 2022. PMID: 35758203 Free PMC article. - Neuroendocrine differentiation in usual-type prostatic adenocarcinoma: Molecular characterization and clinical significance.
Kaur H, Samarska I, Lu J, Faisal F, Maughan BL, Murali S, Asrani K, Alshalalfa M, Antonarakis ES, Epstein JI, Joshu CE, Schaeffer EM, Mosquera JM, Lotan TL. Kaur H, et al. Prostate. 2020 Sep;80(12):1012-1023. doi: 10.1002/pros.24035. Epub 2020 Jul 10. Prostate. 2020. PMID: 32649013 Free PMC article. - Focal Neuroendocrine Differentiation of Conventional Prostate Adenocarcinoma as a Prognostic Factor after Radical Prostatectomy: A Systematic Review and Meta-Analysis.
Kardoust Parizi M, Iwata T, Kimura S, Janisch F, Abufaraj M, Karakiewicz PI, Enikeev D, Rapoport LM, Hutterer G, Shariat SF. Kardoust Parizi M, et al. Int J Mol Sci. 2019 Mar 19;20(6):1374. doi: 10.3390/ijms20061374. Int J Mol Sci. 2019. PMID: 30893781 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Research Materials