Role of the human RAD51 protein in homologous recombination and double-stranded-break repair - PubMed (original) (raw)
Review
Role of the human RAD51 protein in homologous recombination and double-stranded-break repair
P Baumann et al. Trends Biochem Sci. 1998 Jul.
Abstract
Eukaryotic cells possess several mechanisms for repairing double-stranded breaks in DNA. One mechanism involves genetic recombination with an intact sister duplex. The recent identification of the RAD51 protein, a eukaryotic homologue of Escherichia coli RecA, represents a landmark discovery in our understanding of the key reactions in this repair pathway. RAD51 is similar to RecA, both biochemically and structurally: it promotes homologous pairing and strand exchange within a regular nucleoprotein filament. The isolation of yeast and human RecA homologues shows that homologous recombination and recombinational repair have been conserved throughout evolution. The goal is now to identify other factors involved in recombinational repair and to define their roles in this essential process.
Similar articles
- Polarity of DNA strand exchange promoted by recombination proteins of the RecA family.
Gupta RC, Golub EI, Wold MS, Radding CM. Gupta RC, et al. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9843-8. doi: 10.1073/pnas.95.17.9843. Proc Natl Acad Sci U S A. 1998. PMID: 9707563 Free PMC article. - Stimulation by Rad52 of yeast Rad51-mediated recombination.
Shinohara A, Ogawa T. Shinohara A, et al. Nature. 1998 Jan 22;391(6665):404-7. doi: 10.1038/34943. Nature. 1998. PMID: 9450759 - Double-strand break repair: are Rad51/RecA--DNA joints barriers to DNA replication?
Aguilera A. Aguilera A. Trends Genet. 2001 Jun;17(6):318-21. doi: 10.1016/s0168-9525(01)02309-5. Trends Genet. 2001. PMID: 11377793 Review. - The search for the right partner: homologous pairing and DNA strand exchange proteins in eukaryotes.
Heyer WD. Heyer WD. Experientia. 1994 Mar 15;50(3):223-33. doi: 10.1007/BF01924005. Experientia. 1994. PMID: 8143796 Review.
Cited by
- Augmentation of response to chemotherapy by microRNA-506 through regulation of RAD51 in serous ovarian cancers.
Liu G, Yang D, Rupaimoole R, Pecot CV, Sun Y, Mangala LS, Li X, Ji P, Cogdell D, Hu L, Wang Y, Rodriguez-Aguayo C, Lopez-Berestein G, Shmulevich I, De Cecco L, Chen K, Mezzanzanica D, Xue F, Sood AK, Zhang W. Liu G, et al. J Natl Cancer Inst. 2015 May 20;107(7):djv108. doi: 10.1093/jnci/djv108. Print 2015 Jul. J Natl Cancer Inst. 2015. PMID: 25995442 Free PMC article. - Induction of CAF-1 expression in response to DNA strand breaks in quiescent human cells.
Nabatiyan A, Szüts D, Krude T. Nabatiyan A, et al. Mol Cell Biol. 2006 Mar;26(5):1839-49. doi: 10.1128/MCB.26.5.1839-1849.2006. Mol Cell Biol. 2006. PMID: 16479003 Free PMC article. - Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells.
Hochegger H, Dejsuphong D, Fukushima T, Morrison C, Sonoda E, Schreiber V, Zhao GY, Saberi A, Masutani M, Adachi N, Koyama H, de Murcia G, Takeda S. Hochegger H, et al. EMBO J. 2006 Mar 22;25(6):1305-14. doi: 10.1038/sj.emboj.7601015. Epub 2006 Feb 23. EMBO J. 2006. PMID: 16498404 Free PMC article. - RAD51 and DMC1 form mixed complexes associated with mouse meiotic chromosome cores and synaptonemal complexes.
Tarsounas M, Morita T, Pearlman RE, Moens PB. Tarsounas M, et al. J Cell Biol. 1999 Oct 18;147(2):207-20. doi: 10.1083/jcb.147.2.207. J Cell Biol. 1999. PMID: 10525529 Free PMC article. - Analysis of the Xenopus Werner syndrome protein in DNA double-strand break repair.
Yan H, McCane J, Toczylowski T, Chen C. Yan H, et al. J Cell Biol. 2005 Oct 24;171(2):217-27. doi: 10.1083/jcb.200502077. J Cell Biol. 2005. PMID: 16247024 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials