GTPase-activating proteins: helping hands to complement an active site - PubMed (original) (raw)
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GTPase-activating proteins: helping hands to complement an active site
K Scheffzek et al. Trends Biochem Sci. 1998 Jul.
Abstract
Stimulation of the intrinsic GTPase activity of GTP-binding proteins by GTPase-activating proteins (GAPs) is a basic principle of GTP-binding-protein downregulation. Recently, the molecular mechanism behind this reaction has been elucidated by studies on Ras and Rho, and their respective GAPs. The basic features involve stabilizing the existing catalytic machinery and supplementing it by an external arginine residue. This represents a novel mechanism for enzyme active-site formation.
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