Electrical stimulation of the prefrontal cortex increases cholecystokinin, glutamate, and dopamine release in the nucleus accumbens: an in vivo microdialysis study in freely moving rats - PubMed (original) (raw)

Fig. 3.

Effect of forced stimulation at various intensities on extracellular CCK, Glu, DA, DOPAC, and HVA levels in the NAS. The stimulation parameters were the same as in Figure 2, except that stimulation frequency was fixed at 100 Hz, whereas stimulation current was varied. Circles, 700 μA;squares, 500 μA; upward and_downward triangles_, 250 and 50 μA, respectively. The data were analyzed using a two-way ANOVA with repeated measures over time, followed by Fisher’s LSD test. n = 6–7 in each group. For CCK: treatment, F(3,21) = 5.47; p < 0.01; time,F(5,105) = 30.58; p < 0.001; interaction,F(15,105) = 3.68; p < 0.001. For Glu: treatment, F(3,20) = 8.56;p < 0.001; time,F(5,100) = 13.49; p < 0.001; interaction, F(15,100) = 2.17;p < 0.01. For DA: treatment,F(3,21) = 0.80; p = 0.51; time, F(5,105) = 8.95;p < 0.001; interaction,F(15,105) = 2.44; p < 0.02. For DOPAC: treatment, F(3,21) = 4.59;p < 0.01; time,F(5,105) = 10.76; p < 0.001; interaction, F(15,105) = 3.224;p < 0.001. For HVA: treatment,F(3,21) = 2.65; p = 0.07; time, F(5,105) = 7.22;p < 0.001; interaction,F(15,105) = 1.91; p < 0.05. *p < 0.05; **p < 0.01, compared with respective baseline values.