A common neural progenitor for the CNS and PNS - PubMed (original) (raw)
. 1998 Aug 1;200(1):1-15.
doi: 10.1006/dbio.1998.8913.
Affiliations
- PMID: 9698451
- DOI: 10.1006/dbio.1998.8913
Free article
A common neural progenitor for the CNS and PNS
T Mujtaba et al. Dev Biol. 1998.
Free article
Abstract
Cultured spinal cord neuroepithelial (NEP) cells can differentiate into neurons, oligodendrocytes and astrocytes and are morphologically and antigenically distinct from neural crest stem cells (NCSCs) that generate the PNS. NEP cells, however, can generate p75/nestin-immunoreactive cells that are morphologically and antigenically similar to previously characterized NCSCs. NEP-derived p75-immunoreactive cells differentiate into peripheral neurons, smooth muscle, and Schwann cells in mass and clonal culture. Clonal analysis of NEP cells demonstrates that a common NEP progenitor cell generated both CNS and PNS phenotypes. Differentiation into NCSCs was promoted by BMP-2/4 and differentiation did not require cells to divide, indicating that BMP played an instructive role in the differentiation process. Thus, individual NEP cells are multipotent and can differentiate into most major types of cell in the CNS and PNS and that PNS differentiation involves a transition from a NEP stem to another more limited, p75-immunoreactive, neural crest stem cell.
Copyright 1998 Academic Press.
Similar articles
- Neuroepithelial stem cells from the embryonic spinal cord: isolation, characterization, and clonal analysis.
Kalyani A, Hobson K, Rao MS. Kalyani A, et al. Dev Biol. 1997 Jun 15;186(2):202-23. doi: 10.1006/dbio.1997.8592. Dev Biol. 1997. PMID: 9205140 - Glial-restricted precursors are derived from multipotent neuroepithelial stem cells.
Rao MS, Mayer-Proschel M. Rao MS, et al. Dev Biol. 1997 Aug 1;188(1):48-63. doi: 10.1006/dbio.1997.8597. Dev Biol. 1997. PMID: 9245511 - BMP signaling initiates a neural crest differentiation program in embryonic rat CNS stem cells.
Gajavelli S, Wood PM, Pennica D, Whittemore SR, Tsoulfas P. Gajavelli S, et al. Exp Neurol. 2004 Aug;188(2):205-23. doi: 10.1016/j.expneurol.2004.03.026. Exp Neurol. 2004. PMID: 15246821 - [Boundary cap cells--a nest of neural stem cells in the peripheral nervous system].
Topilko P. Topilko P. Bull Acad Natl Med. 2007 Oct;191(7):1383-92; discussion 1392-4. Bull Acad Natl Med. 2007. PMID: 18447060 Review. French. - Embryonic development of Schwann cells: multiple roles for neuregulins along the pathway.
Topilko P, Murphy P, Charnay P. Topilko P, et al. Mol Cell Neurosci. 1996;8(2-3):71-5. doi: 10.1006/mcne.1996.0045. Mol Cell Neurosci. 1996. PMID: 8918823 Review.
Cited by
- An Early Neoplasia Index (ENI10), Based on Molecular Identity of CD10 Cells and Associated Stemness Biomarkers, is a Predictor of Patient Outcome in Many Cancers.
Guyot B, Clément F, Drouet Y, Schmidt X, Lefort S, Delay E, Treilleux I, Foy JP, Jeanpierre S, Thomas E, Kielbassa J, Tonon L, Zhu HH, Saintigny P, Gao WQ, de la Fouchardiere A, Tirode F, Viari A, Blay JY, Maguer-Satta V. Guyot B, et al. Cancer Res Commun. 2023 Sep 29;3(9):1966-1980. doi: 10.1158/2767-9764.CRC-23-0196. Cancer Res Commun. 2023. PMID: 37707389 Free PMC article. - Dopey2 and Pcdh7 orchestrate the development of embryonic neural stem cells/ progenitors in zebrafish.
Xiao Y, Hu M, Lin Q, Zhang T, Li S, Shu L, Song X, Xu X, Meng W, Li X, Xu H, Mo X. Xiao Y, et al. iScience. 2023 Feb 25;26(3):106273. doi: 10.1016/j.isci.2023.106273. eCollection 2023 Mar 17. iScience. 2023. PMID: 36936789 Free PMC article. - Directing Axonal Growth: A Review on the Fabrication of Fibrous Scaffolds That Promotes the Orientation of Axons.
Sirkkunan D, Pingguan-Murphy B, Muhamad F. Sirkkunan D, et al. Gels. 2021 Dec 28;8(1):25. doi: 10.3390/gels8010025. Gels. 2021. PMID: 35049560 Free PMC article. Review. - Preparation of Neural Stem Cells and Progenitors: Neuronal Production and Grafting Applications.
Zholudeva LV, Jin Y, Qiang L, Lane MA, Fischer I. Zholudeva LV, et al. Methods Mol Biol. 2021;2311:73-108. doi: 10.1007/978-1-0716-1437-2_7. Methods Mol Biol. 2021. PMID: 34033079 Free PMC article. - Human Embryonic Stem Cell-derived Neural Crest Cells Promote Sprouting and Motor Recovery Following Spinal Cord Injury in Adult Rats.
Jones I, Novikova LN, Wiberg M, Carlsson L, Novikov LN. Jones I, et al. Cell Transplant. 2021 Jan-Dec;30:963689720988245. doi: 10.1177/0963689720988245. Cell Transplant. 2021. PMID: 33522309 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials