Thrombin receptor overexpression in malignant and physiological invasion processes - PubMed (original) (raw)

Thrombin receptor overexpression in malignant and physiological invasion processes

S Even-Ram et al. Nat Med. 1998 Aug.

Abstract

Although the involvement of soluble and matrix-immobilized proteases in tumor cell invasion and metastasis is well recognized, the role of proteolytically activated cell surface receptors has not been elucidated. We report here that thrombin receptor, a member of the protease-activated receptor family, is preferentially expressed in highly metastatic human breast carcinoma cell lines and breast carcinoma biopsy specimens. Introduction of thrombin receptor antisense cDNA considerably inhibited the invasion of metastatic breast carcinoma cells in culture through a reconstituted basement membrane. During placental implantation of the human embryo, thrombin receptor is transiently expressed in the invading cytotrophoblasts. These results emphasize the involvement of thrombin receptor in cell invasion associated with tumor progression and normal embryonic development.

PubMed Disclaimer

Similar articles

• Role of thrombin receptor in breast cancer invasiveness.
  Henrikson KP, Salazar SL, Fenton JW 2nd, Pentecost BT. Henrikson KP, et al. Br J Cancer. 1999 Feb;79(3-4):401-6. doi: 10.1038/sj.bjc.6690063. Br J Cancer. 1999. PMID: 10027305 Free PMC article.
• Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells.
  Kamath L, Meydani A, Foss F, Kuliopulos A. Kamath L, et al. Cancer Res. 2001 Aug 1;61(15):5933-40. Cancer Res. 2001. PMID: 11479236
• Selective inhibition of thrombin receptor-mediated Ca2+ entry by protein kinase C beta.
  Xu Y, Ware JA. Xu Y, et al. J Biol Chem. 1995 Oct 13;270(41):23887-90. doi: 10.1074/jbc.270.41.23887. J Biol Chem. 1995. PMID: 7592574
• Kisspeptins and the placenta: regulation of trophoblast invasion.
  Hiden U, Bilban M, Knöfler M, Desoye G. Hiden U, et al. Rev Endocr Metab Disord. 2007 Mar;8(1):31-9. doi: 10.1007/s11154-007-9030-8. Rev Endocr Metab Disord. 2007. PMID: 17351756 Review.
• Role and regulation of the thrombin receptor (PAR-1) in human melanoma.
  Tellez C, Bar-Eli M. Tellez C, et al. Oncogene. 2003 May 19;22(20):3130-7. doi: 10.1038/sj.onc.1206453. Oncogene. 2003. PMID: 12789289 Review.

Cited by

• New Target(s) for RNF43 Regulation: Implications for Therapeutic Strategies.
  Nag JK, Appasamy P, Malka H, Sedley S, Bar-Shavit R. Nag JK, et al. Int J Mol Sci. 2024 Jul 24;25(15):8083. doi: 10.3390/ijms25158083. Int J Mol Sci. 2024. PMID: 39125653 Free PMC article. Review.
• Quantitative diagnosis of HER2 protein expressing breast cancer by single-particle quantum dot imaging.
  Miyashita M, Gonda K, Tada H, Watanabe M, Kitamura N, Kamei T, Sasano H, Ishida T, Ohuchi N. Miyashita M, et al. Cancer Med. 2016 Oct;5(10):2813-2824. doi: 10.1002/cam4.898. Epub 2016 Sep 26. Cancer Med. 2016. PMID: 27666577 Free PMC article.
• Identify lymphatic metastasis-associated genes in mouse hepatocarcinoma cell lines using gene chip.
  Song B, Tang JW, Wang B, Cui XN, Hou L, Sun L, Mao LM, Zhou CH, Du Y, Wang LH, Wang HX, Zheng RS, Sun L. Song B, et al. World J Gastroenterol. 2005 Mar 14;11(10):1463-72. doi: 10.3748/wjg.v11.i10.1463. World J Gastroenterol. 2005. PMID: 15770722 Free PMC article.
• Overexpression of protease-activated receptor-1 contributes to melanoma metastasis via regulation of connexin 43.
  Villares GJ, Dobroff AS, Wang H, Zigler M, Melnikova VO, Huang L, Bar-Eli M. Villares GJ, et al. Cancer Res. 2009 Aug 15;69(16):6730-7. doi: 10.1158/0008-5472.CAN-09-0300. Cancer Res. 2009. PMID: 19679555 Free PMC article.
• Expression of protease-activated receptors and tissue factor in human liver.
  Rullier A, Senant N, Kisiel W, Bioulac-Sage P, Balabaud C, Le Bail B, Rosenbaum J. Rullier A, et al. Virchows Arch. 2006 Jan;448(1):46-51. doi: 10.1007/s00428-005-0078-0. Epub 2005 Sep 29. Virchows Arch. 2006. PMID: 16193294

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology