The alpha-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: a study of 230 European cases. European Consortium on Genetic Susceptibility in Parkinson's Disease - PubMed (original) (raw)
doi: 10.1002/ana.410440221.
A Durr, J Tassin, B Bereznai, T Gasser, V Bonifati, G De Michele, E Fabrizio, G Volpe, O Bandmann, W G Johnson, L I Golbe, M Breteler, G Meco, Y Agid, A Brice, C D Marsden, N W Wood
Affiliations
- PMID: 9708553
- DOI: 10.1002/ana.410440221
The alpha-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: a study of 230 European cases. European Consortium on Genetic Susceptibility in Parkinson's Disease
J Vaughan et al. Ann Neurol. 1998 Aug.
Abstract
We report the results of a screen of 230 European familial index cases of Parkinson's disease for the recently described Ala53Thr mutation in the alpha-synuclein gene in an autosomal dominant Parkinson's disease kindred. No mutations were found from this broad white population, and we therefore conclude that although of great interest, this mutation is a very rare cause of familial Parkinson's disease.
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