The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins - PubMed (original) (raw)
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins
S B McMahon et al. Cell. 1998.
Free article
Abstract
The c-Myc and E2F transcription factors are among the most potent regulators of cell cycle progression in higher eukaryotes. This report describes the isolation of a novel, highly conserved 434 kDa protein, designated TRRAP, which interacts specifically with the c-Myc N terminus and has homology to the ATM/PI3-kinase family. TRRAP also interacts specifically with the E2F-1 transactivation domain. Expression of transdominant mutants of the TRRAP protein or antisense RNA blocks c-Myc- and E1A-mediated oncogenic transformation. These data suggest that TRRAP is an essential cofactor for both the c-Myc and E1A/E2F oncogenic transcription factor pathways.
Similar articles
- p27kip1-independent cell cycle regulation by MYC.
Berns K, Martins C, Dannenberg JH, Berns A, te Riele H, Bernards R. Berns K, et al. Oncogene. 2000 Oct 5;19(42):4822-7. doi: 10.1038/sj.onc.1203879. Oncogene. 2000. PMID: 11039898 - TIP49, but not TRRAP, modulates c-Myc and E2F1 dependent apoptosis.
Dugan KA, Wood MA, Cole MD. Dugan KA, et al. Oncogene. 2002 Aug 29;21(38):5835-43. doi: 10.1038/sj.onc.1205763. Oncogene. 2002. PMID: 12185582 - Recruitment of TRRAP required for oncogenic transformation by E1A.
Deleu L, Shellard S, Alevizopoulos K, Amati B, Land H. Deleu L, et al. Oncogene. 2001 Dec 13;20(57):8270-5. doi: 10.1038/sj.onc.1205159. Oncogene. 2001. PMID: 11781841 - Disruption of cell-cycle control by viral oncoproteins.
Nevins JR. Nevins JR. Biochem Soc Trans. 1993 Nov;21(4):935-8. doi: 10.1042/bst0210935. Biochem Soc Trans. 1993. PMID: 8132097 Review. No abstract available. - Adenovirus E1A: transcription regulation and alteration of cell growth control.
Nevins JR. Nevins JR. Curr Top Microbiol Immunol. 1995;199 ( Pt 3):25-32. doi: 10.1007/978-3-642-79586-2_2. Curr Top Microbiol Immunol. 1995. PMID: 7555080 Review. No abstract available.
Cited by
- Structural Insights into TOR Signaling.
Tafur L, Kefauver J, Loewith R. Tafur L, et al. Genes (Basel). 2020 Aug 4;11(8):885. doi: 10.3390/genes11080885. Genes (Basel). 2020. PMID: 32759652 Free PMC article. Review. - TEAD activity is restrained by MYC and stratifies human breast cancer subtypes.
Elster D, Jaenicke LA, Eilers M, von Eyss B. Elster D, et al. Cell Cycle. 2016 Oct;15(19):2551-2556. doi: 10.1080/15384101.2016.1207837. Epub 2016 Jul 19. Cell Cycle. 2016. PMID: 27433809 Free PMC article. - Myc influences global chromatin structure.
Knoepfler PS, Zhang XY, Cheng PF, Gafken PR, McMahon SB, Eisenman RN. Knoepfler PS, et al. EMBO J. 2006 Jun 21;25(12):2723-34. doi: 10.1038/sj.emboj.7601152. Epub 2006 May 25. EMBO J. 2006. PMID: 16724113 Free PMC article. - Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation.
Nilsson JA, Maclean KH, Keller UB, Pendeville H, Baudino TA, Cleveland JL. Nilsson JA, et al. Mol Cell Biol. 2004 Feb;24(4):1560-9. doi: 10.1128/MCB.24.4.1560-1569.2004. Mol Cell Biol. 2004. PMID: 14749372 Free PMC article. - The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60.
Patel JH, Du Y, Ard PG, Phillips C, Carella B, Chen CJ, Rakowski C, Chatterjee C, Lieberman PM, Lane WS, Blobel GA, McMahon SB. Patel JH, et al. Mol Cell Biol. 2004 Dec;24(24):10826-34. doi: 10.1128/MCB.24.24.10826-10834.2004. Mol Cell Biol. 2004. PMID: 15572685 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous