How is the intracellular fate of the Legionella pneumophila phagosome determined? - PubMed (original) (raw)
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How is the intracellular fate of the Legionella pneumophila phagosome determined?
G Segal et al. Trends Microbiol. 1998 Jul.
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Abstract
The following pair of articles, the first by Gil Segal and Howard Shuman, and the second by James Kirby and Ralph Isberg (Trends Microbiol. 6, 256-258), explore the genetics and function of the icm/dot genes of Legionella pneumophila. This gene family is implicated in several aspects of virulence and appears to constitute components of a conjugal transfer system that has been adopted to prevent phagosome-lysosome fusion in the host cell and to mediate host cytotoxicity by pore formation. Whether these functions are natural consequences or operate in parallel remains to be discovered.
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