Reductive evolution of resident genomes - PubMed (original) (raw)

Review

Reductive evolution of resident genomes

S G Andersson et al. Trends Microbiol. 1998 Jul.

Abstract

Small, asexual populations are expected to accumulate deleterious substitutions and deletions in an irreversible manner, which in the long-term will lead to mutational meltdown and genome decay. Here, we discuss the influence of such reductive processes on the evolution of genomes that replicate within the domain of a host genome.

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