[Fleroxacin treatment for acute uncomplicated cystitis in women: comparison of 3-day and 7-day therapy] - PubMed (original) (raw)

[Article in Japanese]

Y Ban, Y Kawada, S Ito, Y Ito, T Doi, S Nezasa, S Fujihiro, M Yamaha, F Ito, H Iwata, Y Hasegawa, K Ueno, I Shinoda, M Taniguchi, K Minoshima, T Takeuchi, S Sakai, H Uno, T Koide

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Clinical Trial

[Fleroxacin treatment for acute uncomplicated cystitis in women: comparison of 3-day and 7-day therapy]

[Article in Japanese]

S Ishihara et al. Hinyokika Kiyo. 1998 Jun.

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Abstract

The clinical efficacy of fleroxacin (FLRX), a new fluoroquinolone, for acute uncomplicated cystitis (AUC) in women was assessed. Two regimens, 3-day and 7-day courses of FLRX, 200 mg once a day, were compared. Clinical and bacteriological efficacy were evaluated after the therapy, and recurrence rate was evaluated 1 week and 4 weeks after termination of the therapy. Of 136 registered subjects, 35 in the 3-day group and 47 in the 7-day group were evaluated. According to the criteria of Japanese UTI Committee (3rd edition), the rate of excellent results was significantly higher in the 7-day group (78.9%) than in the 3-day group (48.6%), but the overall clinical efficacy rate was similar being 100% and 97.9%, respectively. Although no recurrence was seen 1 week after the therapy in either group, recurrence was seen in 14.3% and 7.4% of the cases in the 3-day and 7-day groups, respectively, 4 weeks after the therapy. Adverse reactions were observed in 2 and 3 cases in the 3-day and 7-day groups, respectively. Both 3-day and 7-day regimens of FLRX treatment showed good efficacy. Although the 7-day treatment was superior to the 3-day treatment as to high rate of excellent results and low rate of recurrence, the 3-day treatment was concluded to be sufficient for AUC.

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