The amphiphysin family of proteins and their role in endocytosis at the synapse - PubMed (original) (raw)

Review

The amphiphysin family of proteins and their role in endocytosis at the synapse

P Wigge et al. Trends Neurosci. 1998 Aug.

Abstract

Clathrin-mediated endocytosis at the plasma membrane is a major pathway of synaptic vesicle recycling in neurones, but little is known about the molecular machinery that orchestrates the process. The amphiphysin protein has recently emerged into the limelight since its discovery in 1992 as a synaptic vesicle-associated protein. It was subsequently found to interact in vitro with the GTPase dynamin through its SH3 domain. However, only in the past year has its role in endocytosis been confirmed, with the demonstration that the introduction of dominant-negative-acting SH3 domains into living cells causes a potent blockade of clathrin-mediated endocytosis. This, together with the discovery by several groups of a second nerve terminal-enriched amphiphysin isoform, and the finding that the two proteins heterodimerize, further suggests that the amphiphysins are closely connected with dynamin-mediated vesicle budding. This review summarizes current views in the field, and draws on data that suggest intriguing alternative roles--including possible involvement in the cytoskeleton and in tumour suppression--for certain members of the amphiphysin family.

PubMed Disclaimer

Cited by

Analysis of the small GTPase gene superfamily of Arabidopsis.
Vernoud V, Horton AC, Yang Z, Nielsen E. Vernoud V, et al. Plant Physiol. 2003 Mar;131(3):1191-208. doi: 10.1104/pp.013052. Plant Physiol. 2003. PMID: 12644670 Free PMC article.
Membrane Mechanics of Endocytosis in Cells with Turgor.
Dmitrieff S, Nédélec F. Dmitrieff S, et al. PLoS Comput Biol. 2015 Oct 30;11(10):e1004538. doi: 10.1371/journal.pcbi.1004538. eCollection 2015 Oct. PLoS Comput Biol. 2015. PMID: 26517669 Free PMC article.
Syndapin promotes formation of a postsynaptic membrane system in Drosophila.
Kumar V, Fricke R, Bhar D, Reddy-Alla S, Krishnan KS, Bogdan S, Ramaswami M. Kumar V, et al. Mol Biol Cell. 2009 Apr;20(8):2254-64. doi: 10.1091/mbc.e08-10-1072. Epub 2009 Feb 25. Mol Biol Cell. 2009. PMID: 19244343 Free PMC article.
Lysoplex: An efficient toolkit to detect DNA sequence variations in the autophagy-lysosomal pathway.
Di Fruscio G, Schulz A, De Cegli R, Savarese M, Mutarelli M, Parenti G, Banfi S, Braulke T, Nigro V, Ballabio A. Di Fruscio G, et al. Autophagy. 2015;11(6):928-38. doi: 10.1080/15548627.2015.1043077. Autophagy. 2015. PMID: 26075876 Free PMC article.
Trafficking of gap junction channels at a vertebrate electrical synapse in vivo.
Flores CE, Nannapaneni S, Davidson KG, Yasumura T, Bennett MV, Rash JE, Pereda AE. Flores CE, et al. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):E573-82. doi: 10.1073/pnas.1121557109. Epub 2012 Feb 7. Proc Natl Acad Sci U S A. 2012. PMID: 22323580 Free PMC article.

The amphiphysin family of proteins and their role in endocytosis at the synapse - PubMed (original) (raw)