Cre mutants with altered DNA binding properties - PubMed (original) (raw)

• A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types.
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• Evaluation of a library of loxP variants with a wide range of recombination efficiencies by Cre.
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• mTORC1 regulates high levels of protein synthesis in retinal ganglion cells of adult mice.
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• Mechanisms of Cre recombinase synaptic complex assembly and activation illuminated by Cryo-EM.
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• CRISPR/Cas9-mediated base-editing enables a chain reaction through sequential repair of sgRNA scaffold mutations.
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