Hypocalcemic effect of osteoclastogenesis inhibitory factor/osteoprotegerin in the thyroparathyroidectomized rat - PubMed (original) (raw)
Hypocalcemic effect of osteoclastogenesis inhibitory factor/osteoprotegerin in the thyroparathyroidectomized rat
M Yamamoto et al. Endocrinology. 1998 Sep.
Abstract
Osteoclastogenesis inhibitory factor (OCIF), also termed as osteoprotegerin (OPG), is a soluble member of the tumor necrosis factor receptor family. Although OCIF/OPG is shown to inhibit osteoclast formation in vitro and prevent ovariectomy-induced bone loss in vivo, its effect on serum calcium level remains to be determined. In this study we examined the acute effect of OCIF on thyroparathyroidectomized rats whose serum calcium concentrations were raised either by exogenous PTH or 1,25-(OH)2D3. When OCIF was administered at the start of PTH infusion, it attenuated the initial rise in serum calcium. When OCIF was administered into rats with established hypercalcemia, it decreased serum calcium rapidly (within 2 hr) and dramatically. OCIF did not increase urinary calcium excretion. These findings, especially the rapid onset of its hypocalcemic effect, suggest that OCIF not only inhibits the formation of osteoclasts but also affects the function and/or survival of mature osteoclasts at doses used in this study.
Similar articles
- Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro.
Yasuda H, Shima N, Nakagawa N, Mochizuki SI, Yano K, Fujise N, Sato Y, Goto M, Yamaguchi K, Kuriyama M, Kanno T, Murakami A, Tsuda E, Morinaga T, Higashio K. Yasuda H, et al. Endocrinology. 1998 Mar;139(3):1329-37. doi: 10.1210/endo.139.3.5837. Endocrinology. 1998. PMID: 9492069 - Transforming growth factor-beta1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoclast-like cells.
Murakami T, Yamamoto M, Ono K, Nishikawa M, Nagata N, Motoyoshi K, Akatsu T. Murakami T, et al. Biochem Biophys Res Commun. 1998 Nov 27;252(3):747-52. doi: 10.1006/bbrc.1998.9723. Biochem Biophys Res Commun. 1998. PMID: 9837778 - In vivo administration of 1,25-dihydroxyvitamin D3 suppresses the expression of RANKL mRNA in bone of thyroparathyroidectomized rats constantly infused with PTH.
Ueno Y, Shinki T, Nagai Y, Murayama H, Fujii K, Suda T. Ueno Y, et al. J Cell Biochem. 2003 Oct 1;90(2):267-77. doi: 10.1002/jcb.10623. J Cell Biochem. 2003. PMID: 14505343 - [Osteoclastogenesis inhibitory factor (OCIF)/OPG].
Tsuda E, Higashio K. Tsuda E, et al. Nihon Rinsho. 1998 Jun;56(6):1435-9. Nihon Rinsho. 1998. PMID: 9648461 Review. Japanese. - [Osteoclastogenesis Inhibitory Factor (OCIF) /Osteoprotegerin (OPG) as a new therapeutic agent for osteoporosis].
Mochizuki S, Kiyokawa A, Nagayama Y. Mochizuki S, et al. Clin Calcium. 2005 Jan;15(1):35-42. Clin Calcium. 2005. PMID: 15632471 Review. Japanese.
Cited by
- Oral administration activity determination of recombinant osteoprotegerin from silkworm larvae.
Xiao HL, Zhang YZ, Wu XF. Xiao HL, et al. Mol Biotechnol. 2007 Feb;35(2):179-84. doi: 10.1007/BF02686103. Mol Biotechnol. 2007. PMID: 17435284 - The effects of osteoprotegerin on the mechanical properties of rat bone.
Ross AB, Bateman TA, Kostenuik PJ, Ferguson VL, Lacey DL, Dunstan CR, Simske SJ. Ross AB, et al. J Mater Sci Mater Med. 2001 Jul;12(7):583-8. doi: 10.1023/a:1011229324412. J Mater Sci Mater Med. 2001. PMID: 15348250 - Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis.
Romas E, Sims NA, Hards DK, Lindsay M, Quinn JW, Ryan PF, Dunstan CR, Martin TJ, Gillespie MT. Romas E, et al. Am J Pathol. 2002 Oct;161(4):1419-27. doi: 10.1016/S0002-9440(10)64417-3. Am J Pathol. 2002. PMID: 12368214 Free PMC article. - Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.
Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I, Wang L, Xia XZ, Elliott R, Chiu L, Black T, Scully S, Capparelli C, Morony S, Shimamoto G, Bass MB, Boyle WJ. Hsu H, et al. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3540-5. doi: 10.1073/pnas.96.7.3540. Proc Natl Acad Sci U S A. 1999. PMID: 10097072 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources