Transcription of a minimal promoter from the NF-IL6 gene is regulated by CREB/ATF and SP1 proteins in U937 promonocytic cells - PubMed (original) (raw)
. 1998 Sep 1;161(5):2267-75.
Affiliations
- PMID: 9725220
Transcription of a minimal promoter from the NF-IL6 gene is regulated by CREB/ATF and SP1 proteins in U937 promonocytic cells
A Berrier et al. J Immunol. 1998.
Abstract
NF-IL6 is an important transcriptional regulator of genes induced in activated monocytes/macrophages, and NF-IL6 is the only CCAAT/enhancer-binding protein (C/EBP) family member whose steady-state mRNA levels increase upon activation of monocytes (1). We show that increased transcription of the NF-IL6 gene is responsible, at least in part, for induction of NF-IL6 mRNA following activation of U937 promonocytic cells. We have identified a 104-bp minimal promoter region of the NF-IL6 gene that is sufficient for basal and activation-dependent induction of transcription in U937 cells. This region contains binding sites for the cAMP response element-binding protein/activation transcription factor (CREB/ATF) and Sp1 families of transcription factors. Each site is functionally important and contributes independently to transcription of the NF-IL6 gene in U937 cells.
Similar articles
- A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages.
Matsumoto M, Tanaka T, Kaisho T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Akira S. Matsumoto M, et al. J Immunol. 1999 Nov 1;163(9):5039-48. J Immunol. 1999. PMID: 10528209 - Involvement of the transcription factor NF-IL6 in phorbol ester induction of P-glycoprotein in U937 cells.
Combates NJ, Kwon PO, Rzepka RW, Cohen D. Combates NJ, et al. Cell Growth Differ. 1997 Feb;8(2):213-9. Cell Growth Differ. 1997. PMID: 9040943 - The CREB/ATF family of transcription factors: modulation by reversible phosphorylation.
Papavassiliou AG. Papavassiliou AG. Anticancer Res. 1994 Sep-Oct;14(5A):1801-5. Anticancer Res. 1994. PMID: 7847813 Review. - Neuroglial ATF/CREB factors interact with the human immunodeficiency virus type 1 long terminal repeat.
Krebs FC, Goodenow MM, Wigdahl B. Krebs FC, et al. J Neurovirol. 1997 May;3 Suppl 1:S28-32. J Neurovirol. 1997. PMID: 9179787 Review. No abstract available.
Cited by
- Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4.
Gupta S, Jiang M, Anthony A, Pernis AB. Gupta S, et al. J Exp Med. 1999 Dec 20;190(12):1837-48. doi: 10.1084/jem.190.12.1837. J Exp Med. 1999. PMID: 10601358 Free PMC article. - Catecholamines induce IL-10 release in patients suffering from acute myocardial infarction by transactivating its promoter in monocytic but not in T-cells.
Riese U, Brenner S, Döcke WD, Prösch S, Reinke P, Oppert M, Volk HD, Platzer C. Riese U, et al. Mol Cell Biochem. 2000 Sep;212(1-2):45-50. Mol Cell Biochem. 2000. PMID: 11108135 - Interleukin-10 induces inhibitory C/EBPbeta through STAT-3 and represses HIV-1 transcription in macrophages.
Tanaka N, Hoshino Y, Gold J, Hoshino S, Martiniuk F, Kurata T, Pine R, Levy D, Rom WN, Weiden M. Tanaka N, et al. Am J Respir Cell Mol Biol. 2005 Oct;33(4):406-11. doi: 10.1165/rcmb.2005-0140OC. Epub 2005 Jul 13. Am J Respir Cell Mol Biol. 2005. PMID: 16014896 Free PMC article. - Analysis of Response Elements Involved in the Regulation of the Human Neonatal Fc Receptor Gene (FCGRT).
Mikulska JE. Mikulska JE. PLoS One. 2015 Aug 7;10(8):e0135141. doi: 10.1371/journal.pone.0135141. eCollection 2015. PLoS One. 2015. PMID: 26252948 Free PMC article. - The role of C/EBPbeta in mammary gland development and breast cancer.
Grimm SL, Rosen JM. Grimm SL, et al. J Mammary Gland Biol Neoplasia. 2003 Apr;8(2):191-204. doi: 10.1023/a:1025900908026. J Mammary Gland Biol Neoplasia. 2003. PMID: 14635794 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Molecular Biology Databases