Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway - PubMed (original) (raw)

Review

Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway

J E Darnell Jr. J Interferon Cytokine Res. 1998 Aug.

Abstract

Sharing the Milstein Award with George R. Stark and Ian M. Kerr in the fall of 1997 brought this invitation to record personal reflections on our experiments concerning the mechanisms of action of interferon. Our work and that of the Kerr and Stark laboratories uncovered the Jak-Stat pathway through which signals from cell surface receptors reach genes in the cell nucleus. This review concentrates on that to which I can speak most reliably, that is, experiments done by my young colleagues at Rockefeller University.

PubMed Disclaimer

Similar articles

• The JAK-STAT pathway: summary of initial studies and recent advances.
  Darnell JE Jr. Darnell JE Jr. Recent Prog Horm Res. 1996;51:391-403; discussion 403-4. Recent Prog Horm Res. 1996. PMID: 8701087 Review.
• Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.
  Takaoka A, Tanaka N, Mitani Y, Miyazaki T, Fujii H, Sato M, Kovarik P, Decker T, Schlessinger J, Taniguchi T. Takaoka A, et al. EMBO J. 1999 May 4;18(9):2480-8. doi: 10.1093/emboj/18.9.2480. EMBO J. 1999. PMID: 10228162 Free PMC article.
• The Jak-STAT pathway stimulated by interferon gamma.
  Horvath CM. Horvath CM. Sci STKE. 2004 Nov 23;2004(260):tr8. doi: 10.1126/stke.2602004tr8. Sci STKE. 2004. PMID: 15561980
• Cytokines and JAK-STAT signaling.
  Schindler C. Schindler C. Exp Cell Res. 1999 Nov 25;253(1):7-14. doi: 10.1006/excr.1999.4670. Exp Cell Res. 1999. PMID: 10579906 Review.

Cited by

• Localization of type I interferon receptor limits interferon-induced TLR3 in epithelial cells.
  Ciencewicki JM, Brighton LE, Jaspers I. Ciencewicki JM, et al. J Interferon Cytokine Res. 2009 May;29(5):289-97. doi: 10.1089/jir.2008.0075. J Interferon Cytokine Res. 2009. PMID: 19231996 Free PMC article.
• CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner.
  Zhai W, Ye X, Wang Y, Feng Y, Wang Y, Lin Y, Ding L, Yang L, Wang X, Kuang Y, Fu X, Eugene Chin Y, Jia B, Zhu B, Ren F, Chang Z. Zhai W, et al. Br J Cancer. 2021 Apr;124(8):1437-1448. doi: 10.1038/s41416-021-01269-1. Epub 2021 Feb 3. Br J Cancer. 2021. PMID: 33531691 Free PMC article.
• Occludin regulates HIV-1 infection by modulation of the interferon stimulated OAS gene family.
  Torices S, Teglas T, Naranjo O, Fattakhov N, Frydlova K, Cabrera R, Osborne OM, Sun E, Kluttz A, Toborek M. Torices S, et al. Res Sq [Preprint]. 2023 Jan 30:rs.3.rs-2501091. doi: 10.21203/rs.3.rs-2501091/v1. Res Sq. 2023. PMID: 36778388 Free PMC article. Updated. Preprint.
• IRF and STAT Transcription Factors - From Basic Biology to Roles in Infection, Protective Immunity, and Primary Immunodeficiencies.
  Mogensen TH. Mogensen TH. Front Immunol. 2019 Jan 8;9:3047. doi: 10.3389/fimmu.2018.03047. eCollection 2018. Front Immunol. 2019. PMID: 30671054 Free PMC article. Review.
• Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B.
  Ganster RW, Taylor BS, Shao L, Geller DA. Ganster RW, et al. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8638-43. doi: 10.1073/pnas.151239498. Epub 2001 Jul 3. Proc Natl Acad Sci U S A. 2001. PMID: 11438703 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon

• Other Literature Sources

  • The Lens - Patent Citations Database