Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons - PubMed (original) (raw)

Comparative Study

. 1998 Aug 21;94(4):503-14.

doi: 10.1016/s0092-8674(00)81591-3.

Affiliations

• PMID: 9727493
• DOI: 10.1016/s0092-8674(00)81591-3

Free article

Comparative Study

Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons

S Sockanathan et al. Cell. 1998.

Free article

Abstract

The diversification of neuronal cell types in the vertebrate central nervous system depends on inductive signals provided by local organizing cell groups of both neural and nonneural origin. The influence of signals provided by postmitotic neurons on the fate of neurons born at subsequent development stages, however, remains unclear. We provide evidence that a retinoid-mediated signal provided by one subset of early-born spinal motor neurons imposes a local variation in the number of motor neurons generated at different axial levels and also specifies the identity of a later-born subset of motor neurons. Thus, in the vertebrate central nervous system the distinct fates of late-born neurons may be acquired in response to signals provided by early-born neurons.

PubMed Disclaimer

Similar articles

• Mesodermal and neuronal retinoids regulate the induction and maintenance of limb innervating spinal motor neurons.
  Ji SJ, Zhuang B, Falco C, Schneider A, Schuster-Gossler K, Gossler A, Sockanathan S. Ji SJ, et al. Dev Biol. 2006 Sep 1;297(1):249-61. doi: 10.1016/j.ydbio.2006.05.015. Epub 2006 May 19. Dev Biol. 2006. PMID: 16781703
• Retinoid receptor signaling in postmitotic motor neurons regulates rostrocaudal positional identity and axonal projection pattern.
  Sockanathan S, Perlmann T, Jessell TM. Sockanathan S, et al. Neuron. 2003 Sep 25;40(1):97-111. doi: 10.1016/s0896-6273(03)00532-4. Neuron. 2003. PMID: 14527436
• A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification.
  Novitch BG, Wichterle H, Jessell TM, Sockanathan S. Novitch BG, et al. Neuron. 2003 Sep 25;40(1):81-95. doi: 10.1016/j.neuron.2003.08.006. Neuron. 2003. PMID: 14527435
• The generation and diversification of spinal motor neurons: signals and responses.
  Price SR, Briscoe J. Price SR, et al. Mech Dev. 2004 Sep;121(9):1103-15. doi: 10.1016/j.mod.2004.04.019. Mech Dev. 2004. PMID: 15296975 Review.
• Retinoids run rampant: multiple roles during spinal cord and motor neuron development.
  Appel B, Eisen JS. Appel B, et al. Neuron. 2003 Oct 30;40(3):461-4. doi: 10.1016/s0896-6273(03)00688-3. Neuron. 2003. PMID: 14642271 Review.

Cited by

• Molecular basis for catecholaminergic neuron diversity.
  Grimm J, Mueller A, Hefti F, Rosenthal A. Grimm J, et al. Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13891-6. doi: 10.1073/pnas.0405340101. Epub 2004 Sep 7. Proc Natl Acad Sci U S A. 2004. PMID: 15353588 Free PMC article.
• Lateral motor column axons execute a ternary trajectory choice between limb and body tissues.
  Luria V, Laufer E. Luria V, et al. Neural Dev. 2007 Jul 2;2:13. doi: 10.1186/1749-8104-2-13. Neural Dev. 2007. PMID: 17605791 Free PMC article.
• Retinoic acid is a potential dorsalising signal in the late embryonic chick hindbrain.
  Wilson LJ, Myat A, Sharma A, Maden M, Wingate RJ. Wilson LJ, et al. BMC Dev Biol. 2007 Dec 19;7:138. doi: 10.1186/1471-213X-7-138. BMC Dev Biol. 2007. PMID: 18093305 Free PMC article.
• Retinoic acid treatment recruits macrophages and increases axonal regeneration after optic nerve injury in the frog Rana pipiens.
  De La Rosa-Reyes V, Duprey-Díaz MV, Blagburn JM, Blanco RE. De La Rosa-Reyes V, et al. PLoS One. 2021 Nov 5;16(11):e0255196. doi: 10.1371/journal.pone.0255196. eCollection 2021. PLoS One. 2021. PMID: 34739478 Free PMC article.
• Emergence of motor circuit activity.
  Law C, Paquet M, Kania A. Law C, et al. PLoS One. 2014 Apr 10;9(4):e93836. doi: 10.1371/journal.pone.0093836. eCollection 2014. PLoS One. 2014. PMID: 24722186 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • Gene Ontology