TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3 - PubMed (original) (raw)
Comparative Study
. 1998 Sep 11;435(1):39-44.
doi: 10.1016/s0014-5793(98)01031-x.
P M Slocombe, A Webster, M Butler, C G Knight, B J Smith, P E Stephens, C Shelley, M Hutton, V Knäuper, A J Docherty, G Murphy
Affiliations
- PMID: 9755855
- DOI: 10.1016/s0014-5793(98)01031-x
Free article
Comparative Study
TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3
A Amour et al. FEBS Lett. 1998.
Free article
Abstract
TNF-alpha converting enzyme (TACE; ADAM-17) is a membrane-bound disintegrin metalloproteinase that processes the membrane-associated cytokine proTNF-alpha to a soluble form. Because of its putative involvement in inflammatory diseases, TACE represents a significant target for the design of specific synthetic inhibitors as therapeutic agents. In order to study its inhibition by tissue inhibitors of metalloproteinases (TIMPs) and synthetic inhibitors of metalloproteinases, the catalytic domain of mouse TACE (rTACE) was overexpressed as a soluble Ig fusion protein from NS0 cells. rTACE was found to be well inhibited by peptide hydroxamate inhibitors as well as by TIMP-3 but not by TIMP-1, -2 and -4. These results suggest that TIMP-3, unlike the other TIMPs, may be important in the modulation of pathological events in which TNF-alpha secretion is involved.
Similar articles
- CD30 shedding from Karpas 299 lymphoma cells is mediated by TNF-alpha-converting enzyme.
Hansen HP, Dietrich S, Kisseleva T, Mokros T, Mentlein R, Lange HH, Murphy G, Lemke H. Hansen HP, et al. J Immunol. 2000 Dec 15;165(12):6703-9. doi: 10.4049/jimmunol.165.12.6703. J Immunol. 2000. PMID: 11120787 - Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.
Moss ML, Jin SL, Milla ME, Bickett DM, Burkhart W, Carter HL, Chen WJ, Clay WC, Didsbury JR, Hassler D, Hoffman CR, Kost TA, Lambert MH, Leesnitzer MA, McCauley P, McGeehan G, Mitchell J, Moyer M, Pahel G, Rocque W, Overton LK, Schoenen F, Seaton T, Su JL, Becherer JD, et al. Moss ML, et al. Nature. 1997 Feb 20;385(6618):733-6. doi: 10.1038/385733a0. Nature. 1997. PMID: 9034191 - Full-length and N-TIMP-3 display equal inhibitory activities toward TNF-alpha convertase.
Lee MH, Knäuper V, Becherer JD, Murphy G. Lee MH, et al. Biochem Biophys Res Commun. 2001 Jan 26;280(3):945-50. doi: 10.1006/bbrc.2000.4192. Biochem Biophys Res Commun. 2001. PMID: 11162616 - Tumor necrosis factor-alpha converting enzyme.
Black RA. Black RA. Int J Biochem Cell Biol. 2002 Jan;34(1):1-5. doi: 10.1016/s1357-2725(01)00097-8. Int J Biochem Cell Biol. 2002. PMID: 11733179 Review. - Adamalysins. A family of metzincins including TNF-alpha converting enzyme (TACE).
Killar L, White J, Black R, Peschon J. Killar L, et al. Ann N Y Acad Sci. 1999 Jun 30;878:442-52. doi: 10.1111/j.1749-6632.1999.tb07701.x. Ann N Y Acad Sci. 1999. PMID: 10415747 Review.
Cited by
- The Effect of Tissue Inhibitor of Metalloproteinases on Scar Formation after Spinal Cord Injury.
Mishra RR, Nielsen BE, Trudrung MA, Lee S, Bolstad LJ, Hellenbrand DJ, Hanna AS. Mishra RR, et al. Cells. 2024 Sep 14;13(18):1547. doi: 10.3390/cells13181547. Cells. 2024. PMID: 39329731 Free PMC article. Review. - TACE inhibition: a promising therapeutic intervention against AATF-mediated steatohepatitis to hepatocarcinogenesis.
Srinivas AN, Suresh D, Vishwanath PM, Satish S, Santhekadur PK, Koka S, Kumar DP. Srinivas AN, et al. Mol Oncol. 2024 Aug;18(8):1940-1957. doi: 10.1002/1878-0261.13646. Epub 2024 Apr 1. Mol Oncol. 2024. PMID: 38558505 Free PMC article. - ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1.
Sharifi MA, Wierer M, Dang TA, Milic J, Moggio A, Sachs N, von Scheidt M, Hinterdobler J, Müller P, Werner J, Stiller B, Aherrahrou Z, Erdmann J, Zaliani A, Graettinger M, Reinshagen J, Gul S, Gribbon P, Maegdefessel L, Bernhagen J, Sager HB, Mann M, Schunkert H, Kessler T. Sharifi MA, et al. Circ Res. 2023 Sep 29;133(8):674-686. doi: 10.1161/CIRCRESAHA.123.322737. Epub 2023 Sep 7. Circ Res. 2023. PMID: 37675562 Free PMC article. - A structural model of the iRhom-ADAM17 sheddase complex reveals functional insights into its trafficking and activity.
Kahveci-Türköz S, Bläsius K, Wozniak J, Rinkens C, Seifert A, Kasparek P, Ohm H, Oltzen S, Nieszporek M, Schwarz N, Babendreyer A, Preisinger C, Sedlacek R, Ludwig A, Düsterhöft S. Kahveci-Türköz S, et al. Cell Mol Life Sci. 2023 Apr 29;80(5):135. doi: 10.1007/s00018-023-04783-y. Cell Mol Life Sci. 2023. PMID: 37119365 Free PMC article. - The extracellular microenvironment in immune dysregulation and inflammation in retinal disorders.
Biasella F, Plössl K, Baird PN, Weber BHF. Biasella F, et al. Front Immunol. 2023 Mar 1;14:1147037. doi: 10.3389/fimmu.2023.1147037. eCollection 2023. Front Immunol. 2023. PMID: 36936905 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous