Hox genes: from master genes to micromanagers - PubMed (original) (raw)
Review
. 1998 Sep 24;8(19):R676-8.
doi: 10.1016/s0960-9822(98)70433-6.
Affiliations
- PMID: 9768351
- DOI: 10.1016/s0960-9822(98)70433-6
Free article
Review
Hox genes: from master genes to micromanagers
M Akam. Curr Biol. 1998.
Free article
Abstract
We still have little idea how the differential expression of one 'master' gene can control the morphology of complex structures, but recent studies suggest that the Drosophila Hox gene Ultrabithorax micromanages segment development by manipulating a large number of different targets at many developmental stages.
Similar articles
- Insect evolution: Redesigning the fruitfly.
Gibson G. Gibson G. Curr Biol. 1999 Feb 11;9(3):R86-9. doi: 10.1016/s0960-9822(99)80056-6. Curr Biol. 1999. PMID: 10021382 Review. - Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltere.
Weatherbee SD, Halder G, Kim J, Hudson A, Carroll S. Weatherbee SD, et al. Genes Dev. 1998 May 15;12(10):1474-82. doi: 10.1101/gad.12.10.1474. Genes Dev. 1998. PMID: 9585507 Free PMC article. - Ultrabithorax function in butterfly wings and the evolution of insect wing patterns.
Weatherbee SD, Nijhout HF, Grunert LW, Halder G, Galant R, Selegue J, Carroll S. Weatherbee SD, et al. Curr Biol. 1999 Feb 11;9(3):109-15. doi: 10.1016/s0960-9822(99)80064-5. Curr Biol. 1999. PMID: 10021383 - The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila.
Diez del Corral R, Aroca P, G mez-Skarmeta JL, Cavodeassi F, Modolell J. Diez del Corral R, et al. Genes Dev. 1999 Jul 1;13(13):1754-61. doi: 10.1101/gad.13.13.1754. Genes Dev. 1999. PMID: 10398687 Free PMC article. - Ci: a complex transducer of the hedgehog signal.
Aza-Blanc P, Kornberg TB. Aza-Blanc P, et al. Trends Genet. 1999 Nov;15(11):458-62. doi: 10.1016/s0168-9525(99)01869-7. Trends Genet. 1999. PMID: 10529809 Review.
Cited by
- Hox go omics: insights from Drosophila into Hox gene targets.
Pavlopoulos A, Akam M. Pavlopoulos A, et al. Genome Biol. 2007;8(3):208. doi: 10.1186/gb-2007-8-3-208. Genome Biol. 2007. PMID: 17397522 Free PMC article. Review. - MicroRNA targets in Drosophila.
Enright AJ, John B, Gaul U, Tuschl T, Sander C, Marks DS. Enright AJ, et al. Genome Biol. 2003;5(1):R1. doi: 10.1186/gb-2003-5-1-r1. Epub 2003 Dec 12. Genome Biol. 2003. PMID: 14709173 Free PMC article. - Genome-wide analysis of the binding of the Hox protein Ultrabithorax and the Hox cofactor Homothorax in Drosophila.
Choo SW, White R, Russell S. Choo SW, et al. PLoS One. 2011 Apr 5;6(4):e14778. doi: 10.1371/journal.pone.0014778. PLoS One. 2011. PMID: 21483667 Free PMC article. - Evolution of a novel appendage ground plan in water striders is driven by changes in the Hox gene Ultrabithorax.
Khila A, Abouheif E, Rowe L. Khila A, et al. PLoS Genet. 2009 Jul;5(7):e1000583. doi: 10.1371/journal.pgen.1000583. Epub 2009 Jul 31. PLoS Genet. 2009. PMID: 19649305 Free PMC article. - Emergence of tissue sensitivity to Hox protein levels underlies the evolution of an adaptive morphological trait.
Refki PN, Armisén D, Crumière AJ, Viala S, Khila A. Refki PN, et al. Dev Biol. 2014 Aug 15;392(2):441-53. doi: 10.1016/j.ydbio.2014.05.021. Epub 2014 Jun 2. Dev Biol. 2014. PMID: 24886828 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases