Cell death throes - PubMed (original) (raw)

Cell death throes

S Cory. Proc Natl Acad Sci U S A. 1998.

No abstract available

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Figures

Figure 1

Regulation of DNA fragmentation during apoptosis. ICAD/DFF45 binds tightly to the nuclease CAD/DFF40 and inhibits it. When caspase-3 is activated, it cleaves ICAD/DFF45, thereby releasing CAD/DFF40 to cleave DNA.

Figure 2

Pathways to cell death in C. elegans and mammals (see text).

Comment on

• Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45.
  Zhang J, Liu X, Scherer DC, van Kaer L, Wang X, Xu M. Zhang J, et al. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12480-5. doi: 10.1073/pnas.95.21.12480. Proc Natl Acad Sci U S A. 1998. PMID: 9770511 Free PMC article.

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